LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients
Daniel Ysselstein(Northwestern University), Dimitri Krainc(Saint Thomas - Rutherford Hospital)
Cited by 195
Related Papers
Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells
|Journal of Neuroscience|2011|383
Deficiency of ATP13A2 Leads to Lysosomal Dysfunction, α-Synuclein Accumulation, and Neurotoxicity
|Journal of Neuroscience|2012|288
Activation of -Glucocerebrosidase Reduces Pathological -Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons
|Journal of Neuroscience|2016|275
Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain
|Nature Neuroscience|2019|185
Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
|Nature Communications|2021|183