Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells

Lei Miao(Guangzhou Medical University), Jingjing Qi(Sun Yat-sen University Cancer Center), Qi Zhao(Sun Yat-sen University Cancer Center), Qi-Nian Wu(Sun Yat-sen University), Da‐Liang Wei(Sun Yat-sen University), Xiao-Li Wei(Sun Yat-sen University), Jia Liu(Sun Yat-sen University Cancer Center), Jun Chen(Sun Yat-sen University), Zhao-Lei Zeng(Sun Yat-sen University), Huai‐Qiang Ju(Sun Yat-sen University Cancer Center), Hui Luo(Sun Yat-sen University), Rui‐Hua Xu(Sun Yat-sen University Cancer Center)
Theranostics
December 6, 2019
10.7150/thno.37745
Cited by 182Open Access
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Abstract

: This study evaluated effects of targeting STING in TAMs in anti-gastric-cancer therapies. Moreover, we unveil a novel function of STING to activate the IL6R-JAK-IL24 pathway in macrophages.

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