A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

Sajid Khan(University of Florida), Xuan Zhang(University of Florida), Dongwen Lv(University of Florida), Qi Zhang(The University of Texas MD Anderson Cancer Center), Yonghan He(University of Florida), Peiyi Zhang(University of Florida), Xingui Liu(University of Florida), Dinesh Thummuri(University of Florida), Yaxia Yuan(University of Florida), J Wiegand(University of Florida), Jing Pei(University of Florida), Weizhou Zhang(University of Florida), Abhisheak Sharma(University of Florida), Christopher R. McCurdy(University of Florida), Vinitha M. Kuruvilla(The University of Texas MD Anderson Cancer Center), Natalia Baran(The University of Texas MD Anderson Cancer Center), Adolfo A. Ferrando(Cancer Genetics (United States)), Yong‐Mi Kim(Children's Hospital of Los Angeles), Anna Rogojina(The University of Texas Health Science Center at San Antonio), Peter J. Houghton(The University of Texas Health Science Center at San Antonio), Guangcun Huang(The University of Texas Health Science Center at San Antonio), Robert Hromas(The University of Texas Health Science Center at San Antonio), Marina Konopleva(The University of Texas MD Anderson Cancer Center), Guangrong Zheng(University of Florida), Daohong Zhou(University of Florida)
Nature Medicine
December 1, 2019
Cited by 641Open Access
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