Discovery and Characterization of the Potent and Selective P2X4 Inhibitor <i>N</i> -[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile

Stefan Werner(Bayer (Germany)), Andreas Steinmeyer(Bayer (Germany)), Simone I. Schulz(Bayer (Germany)), Michaela Bairlein(Bayer (Germany)), Thomas M. Zollner(Bayer (Germany)), Alexis Laux‐Biehlmann(Bayer (Germany)), Vera Puetter(Bayer (Germany)), R.C. Hillig(Bayer (Germany)), Reinhard Nubbemeyer(Bayer (Germany)), Ioana Berindan‐Neagoe(Institute of Oncology Prof. Dr. Ion Chiricuta), Stefanie Mesch(Bayer (Germany)), Julie K. Klint(Evotec (Germany)), Henrik Dahllöf(Bayer (Germany)), Nico Bräuer(Nuvisan (Germany)), Antonius ter Laak(Bayer (Germany))
Journal of Medicinal Chemistry
November 20, 2019
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