Author response: ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor

Zineb Mounir; Joshua M. Korn; Thomas Westerling; Fallon Lin; C.A. Kirby; Markus Schirle; Gregg McAllister; Greg Hoffman; Nadire Ramadan; Anke Hartung; Feng Yan; D. Randal Kipp; Christopher Quinn; Michelle Fodor; Jason R. Baird; Marie Schoumacher; Ronald A. Meyer; James Deeds; Gilles Buchwalter; Travis Stams; Nicholas Keen; William R. Sellers; Myles Brown; Raymond Pagliarini

doi:10.7554/elife.13964.024

Author response: ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor

Zineb Mounir(Novartis (France)), Joshua M. Korn(Novartis (France)), Thomas Westerling(Harvard University), Fallon Lin(Novartis (France)), C.A. Kirby(Novartis (Switzerland)), Markus Schirle(Novartis (Switzerland)), Gregg McAllister(Novartis (Switzerland)), Greg Hoffman(Novartis (Switzerland)), Nadire Ramadan(Novartis (Switzerland)), Anke Hartung(Genomics Institute of the Novartis Research Foundation), Feng Yan(Novartis (Switzerland)), D. Randal Kipp(Novartis (France)), Christopher Quinn(Novartis (France)), Michelle Fodor(Novartis (France)), Jason R. Baird(Novartis (France)), Marie Schoumacher(Novartis (France)), Ronald A. Meyer(Novartis (France)), James Deeds(Novartis (France)), Gilles Buchwalter(Harvard University), Travis Stams(Novartis (Switzerland)), Nicholas Keen(Novartis (France)), William R. Sellers(Novartis (France)), Myles Brown(Harvard University), Raymond Pagliarini(Novartis (France))

Unknown

April 5, 2016

10.7554/elife.13964.024

Cited by 2Open Access

Full Text

Abstract

The transcription factor ERG recruits the PRMT5 enzyme to methylate the androgen receptor, presenting a post-translational regulatory mechanism that could be therapeutically exploited to control cell proliferation.

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