Multiple organ dysfunction after trauma

Elaine Cole(Queen Mary University of London), Scarlett Gillespie(Queen Mary University of London), Paul Vulliamy(Queen Mary University of London), Karim Brohi(Queen Mary University of London), Hesham Abd El Raouf El Akkad(Queen Mary University of London), Χριστίνα Αποστολίδου(Queen Mary University of London), Rohan Ardley(Queen Mary University of London), Christopher Aylwin(Queen Mary University of London), Christopher Bassford(Queen Mary University of London), Stephen Bonner(Queen Mary University of London), Andrew I. Brooks, Tom Cairns, Maurizio Cecconi(Queen Mary University of London), Felicity Clark, Ged Dempsey(Queen Mary University of London), E Davies(Queen Mary University of London), RI Docking(Queen Mary University of London), J Eddlestone, David Ellis, Julia Evans, Mark Galea(Queen Mary University of London), M Healy(Queen Mary University of London), Daniel Horner, R. Howarth(Queen Mary University of London), Jan O. Jansen, Jason P. Jones, Callum Kaye(Queen Mary University of London), Jeff Keep, Dean Kerslake, J Kilic, M. Leong(Queen Mary University of London), V Martinson(Queen Mary University of London), B McIldowie(Queen Mary University of London), S Michael(Queen Mary University of London), J Millo, Matt Morgan(Queen Mary University of London), Richard O’Leary(Queen Mary University of London), John F. Oram, Laura Ortiz-Ruiz de Gordoa(Queen Mary University of London), Kyle Porter(Queen Mary University of London), Simon Raby(Queen Mary University of London), Jennifer Service, Dominick Shaw, Justin D. Smith, Nathaniel Smith, M. Stotz(Queen Mary University of London), Ewan Thomas(Queen Mary University of London), Mike Thomas(Queen Mary University of London), Anne Vincent, G Ward(Queen Mary University of London), Ingeborg Welters(Queen Mary University of London)
British journal of surgery
November 6, 2019
10.1002/bjs.11361
Cited by 133Open Access
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Abstract

BACKGROUND: The nature of multiple organ dysfunction syndrome (MODS) after traumatic injury is evolving as resuscitation practices advance and more patients survive their injuries to reach critical care. The aim of this study was to characterize contemporary MODS subtypes in trauma critical care at a population level. METHODS: Adult patients admitted to major trauma centre critical care units were enrolled in this 4-week point-prevalence study. MODS was defined by a daily total Sequential Organ Failure Assessment (SOFA) score of more than 5. Hierarchical clustering of SOFA scores over time was used to identify MODS subtypes. RESULTS: Some 440 patients were enrolled, of whom 245 (55·7 per cent) developed MODS. MODS carried a high mortality rate (22·0 per cent versus 0·5 per cent in those without MODS; P < 0·001) and 24·0 per cent of deaths occurred within the first 48 h after injury. Three patterns of MODS were identified, all present on admission. Cluster 1 MODS resolved early with a median time to recovery of 4 days and a mortality rate of 14·4 per cent. Cluster 2 had a delayed recovery (median 13 days) and a mortality rate of 35 per cent. Cluster 3 had a prolonged recovery (median 25 days) and high associated mortality rate of 46 per cent. Multivariable analysis revealed distinct clinical associations for each form of MODS; 24-hour crystalloid administration was associated strongly with cluster 1 (P = 0·009), traumatic brain injury with cluster 2 (P = 0·002) and admission shock severity with cluster 3 (P = 0·003). CONCLUSION: Contemporary MODS has at least three distinct types based on patterns of severity and recovery. Further characterization of MODS subtypes and their underlying pathophysiology may lead to future opportunities for early stratification and targeted interventions.

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