Frontispiece: Modular Synthesis of DOTA‐Metal‐Based PSMA‐Targeted Imaging Agents for MRI and PET of Prostate Cancer
Hans F. Schmitthenner(Rochester Institute of Technology), Damien E. Dobson(Rochester Institute of Technology), Kelsea G. Jones(Rochester Institute of Technology), Nnamdi Akporji(Rochester Institute of Technology), Dana Q. M. Soika(Rochester Institute of Technology), Kent L. Nastiuk(Roswell Park Comprehensive Cancer Center), Joseph P. Hornak(Rochester Institute of Technology)
Cited by 0Open Access
Abstract
Targeted molecular imaging agents (TMIAs) are emerging as important tools for diagnosing cancer and other diseases. In their Communication on page 13848 ff., H. F. Schmitthenner et al. describe a modular approach to TMIA synthesis by introducing a metal atom early on to form an imaging module for MRI or PET. This is coupled with a targeting module in a convergent step to form a selective imaging agent for prostate cancer. By grasping a branch, the colorful toucan emulates the color-matched TMIA by targeting and lighting up the location of a tree in the forest.
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