DNA Framework-Programmed Cell Capture via Topology-Engineered Receptor–Ligand Interactions
Min Li(Shanghai Jiao Tong University), Hong‐Ming Ding(Soochow University), Meihua Lin(China University of Geosciences), Fangfei Yin(Shanghai Jiao Tong University), Lu Song(Shanghai Jiao Tong University), Xiuhai Mao(Shanghai Jiao Tong University), Fan Li(Shanghai Jiao Tong University), Zhilei Ge(Shanghai Jiao Tong University), Lihua Wang(Chinese Academy of Sciences), Xiaolei Zuo(Shanghai Jiao Tong University), Yu‐qiang Ma(Collaborative Innovation Center of Advanced Microstructures), Chunhai Fan(Shanghai Jiao Tong University)
Cited by 187
Abstract
-simplexes harboring 1-3 aptamers targeting epithelial cell adhesion molecule (EpCAM) that are overexpressed on the membrane of tumor cells. The 2-simplex with three aptamers not only shows increased binding affinity (∼19-fold) but prevents endocytosis by cells. By using 2-simplex as the capture probe, we demonstrate the high-efficiency CTC capture, which is challenged in real clinical breast cancer patient samples. This TDF-programmed platform thus provides a powerful means for studying RLIs in physiological settings and for cancer diagnosis.
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