Association of Flavonifractor plautii, a Flavonoid-Degrading Bacterium, with the Gut Microbiome of Colorectal Cancer Patients in India
Ankit Gupta(Indian Institute of Science Education and Research, Bhopal), Darshan B. Dhakan(Indian Institute of Science Education and Research, Bhopal), Abhijit Maji(Indian Institute of Science Education and Research, Bhopal), Rituja Saxena(Indian Institute of Science Education and Research, Bhopal), V. K.(Indian Institute of Science Education and Research, Bhopal), Shruti Mahajan(Indian Institute of Science Education and Research, Bhopal), Joby Pulikkan(Central University of Kerala), Jacob Kurian(Amala Institute of Medical Sciences), Andrés Gómez(University of Minnesota), Joy Scaria(South Dakota State University), Katherine R. Amato(Northwestern University), Ashok Sharma(University of Minnesota), Vineet K. Sharma(Indian Institute of Science Education and Research, Bhopal)
Cited by 243Open Access
Abstract
This study provides novel insights on the CRC-associated microbiome of a unique cohort in India, reveals the potential role of a new bacterium in CRC, and identifies cohort-specific biomarkers, which can potentially be used in noninvasive diagnosis of CRC. The study gains additional significance, as India is among the countries with a very low incidence of CRC, and the diet and lifestyle in India have been associated with a distinct gut microbiome in healthy Indians compared to other global populations. Thus, in this study, we hypothesize a unique relationship between CRC and the gut microbiome in an Indian population.
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