Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism
Alex J. Bott(Rutgers, The State University of New Jersey), Jianliang Shen(Rutgers, The State University of New Jersey), Claudia Tonelli(Cold Spring Harbor Laboratory), Le Zhan(Rutgers, The State University of New Jersey), Nithya Sivaram(Northport VA Medical Center), Ya-Ping Jiang(Northport VA Medical Center), Xufen Yu(Icahn School of Medicine at Mount Sinai), Vrushank Bhatt(Rutgers, The State University of New Jersey), Eric Chiles(Rutgers, The State University of New Jersey), H. Zhong(Rutgers, The State University of New Jersey), Sara Maimouni(Rutgers, The State University of New Jersey), Weiwei Dai(Rutgers, The State University of New Jersey), Stephani Velasquez(Rutgers, The State University of New Jersey), Ji-An Pan(Rutgers, The State University of New Jersey), Nathiya Muthalagu(Cancer Research UK Scotland Institute), Jennifer P. Morton(Cancer Research UK Scotland Institute), Tracy G. Anthony(Rutgers, The State University of New Jersey), Hui Feng(Boston University), Wouter H. Lamers(Amsterdam UMC Location University of Amsterdam), Daniel J. Murphy(Cancer Research UK Scotland Institute), Jessie Yanxiang Guo(Rutgers, The State University of New Jersey), Jian Jin(Icahn School of Medicine at Mount Sinai), Howard C. Crawford(University of Michigan), Lanjing Zhang(Rutgers, The State University of New Jersey), Eileen White(Rutgers, The State University of New Jersey), Richard Z. Lin(Northport VA Medical Center), Xiaoyang Su(Rutgers, The State University of New Jersey), David A. Tuveson(Cold Spring Harbor Laboratory), Wei‐Xing Zong(Rutgers, The State University of New Jersey)
Cited by 193Open Access
Abstract
-driven murine PDAC. Therefore, GLUL-mediated glutamine biosynthesis couples the TCA cycle with nitrogen anabolism and plays a critical role in PDAC.
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