Identification of multidrug-resistant <i>Neisseria gonorrhoeae</i> isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018

Qianqin Yuan(Central South University), Yamei Li(Chinese Academy of Medical Sciences & Peking Union Medical College), Leshan Xiu(Chinese Academy of Medical Sciences & Peking Union Medical College), Chi Zhang(Chinese Academy of Medical Sciences & Peking Union Medical College), Yaoyang Fu(Central South University), Chuanhao Jiang(Central South University), Lingli Tang(Central South University), Junping Peng(Chinese Academy of Medical Sciences & Peking Union Medical College)
Emerging Microbes & Infections
January 1, 2019
10.1080/22221751.2019.1681242
Cited by 54Open Access
Full Text

Abstract

The growing multidrug-resistant Neisseria gonorrhoeae is a serious global threat to gonococcal therapy. During 2017–2018, we identified a rare multidrug-resistant (ceftriaxone and azithromycin) strain (GC250) and four strains (GC185, GC195, GC196 and GC249) with both resistance to ceftriaxone and decreased susceptibility to azithromycin. All strains belonged to NG-STAR ST1143, including the mosaic penA-60.001, which is closely related to ceftriaxone resistance. The characterization of antimicrobial resistance (AMR) determinants and phylogenetic analysis showed these five strains were closely related to internationally spreading ceftriaxone-resistant N. gonorrhoeae FC428, but with higher azithromycin MIC. Findings here demonstrated that this clone not only initiated clonal expansion in China, but acquired azithromycin resistance.

Related Papers

No related papers found

Powered by citation graph analysis