Genetic architecture of subcortical brain structures in 38,851 individuals

Claudia L. Satizábal; Hieab H.H. Adams; Derrek P. Hibar; Charles C. White; Maria J. Knol; Jason L. Stein; Markus Scholz; Muralidharan Sargurupremraj; Neda Jahanshad; Gennady V. Roshchupkin; Albert V. Smith; Joshua C. Bis; Xueqiu Jian; Michelle Luciano; Edith Hofer; Alexander Teumer; Sven J. van der Lee; Jingyun Yang; Lisa R. Yanek; Tom V. Lee; Shuo Li; Yanhui Hu; Jia Yu Koh; John D. Eicher; Sylvane Desrivières; Alejandro Arias Vásquez; Ganesh Chauhan; Lavinia Athanasiu; Miguel E. Rentería; Sung Eun Kim; David Hoehn; Nicola J. Armstrong; Qiang Chen; Avram J. Holmes; Anouk den Braber; Iwona Kłoszewska; Micael Andersson; Thomas Espeseth; O. Grimm; Lucija Abramovic; Saud Alhusaini; Yuri Milaneschi; Martina Papmeyer; Tomas Axelsson; Stefan Ehrlich; Roberto Roiz‐Santiáñez; Bernd Kraemer; Asta K. Håberg; Hannah Jones; G. Bruce Pike; Dan J. Stein; Allison Stevens; Janita Bralten; Meike W. Vernooij; Tamara B. Harris; Irina Filippi; A. Veronica Witte; Tulio Guadalupe; Katharina Wittfeld; Thomas H. Mosley; James T. Becker; Nhat Trung Doan; Saskia P. Hagenaars; Yasaman Saba; Gabriel Cuéllar-Partida; Najaf Amin; Saima Hilal; Kwangsik Nho; Nazanin Mirza‐Schreiber; Konstantinos Arfanakis; Diane M. Becker; David Ames; Aaron L. Goldman; Phil Hyu Lee; Dorret I. Boomsma; Simon Lovestone; Sudheer Giddaluru; Stéphanie Le Hellard; Manuel Mattheisen; Marc M. Bohlken; Dalia Kasperavičiūtė; Lianne Schmaal; Stephen M. Lawrie; Ingrid Agartz; Esther Walton; Diana Tordesillas‐Gutiérrez; Gareth E. Davies; Jean Shin; Jonathan Ipser; Louis Vinke; Martine Hoogman; Tianye Jia; Ralph Burkhardt; Marieke Klein; Fabrice Crivello; Deborah Janowitz; Owen Carmichael; Unn K. Haukvik; Benjamin S. Aribisala; Helena Schmidt; Lachlan T. Strike; Ching‐Yu Cheng; Shannon L. Risacher; Benno Pütz; Debra Fleischman; Amelia A. Assareh; Venkata S. Mattay; Randy L. Buckner; Patrizia Mecocci; Anders M. Dale; Sven Cichon; Marco P. Boks; Mar Matarín; Brenda W.J.H. Penninx; Vince D. Calhoun; M. Mallar Chakravarty; André F. Marquand; Christine Macare; Shahrzad Kharabian Masouleh; Jaap Oosterlaan; Philippe Amouyel; Katrin Hegenscheid; Jerome I. Rotter; Andrew J. Schork; David C. Liewald; Greig I. de Zubicaray; Tien Yin Wong; Li Shen; Philipp G. Sämann; Henry Brodaty; Joshua L. Roffman; Eco J. C. de Geus; Magda Tsolaki; Susanne Erk; Kristel R. van Eijk; Gianpiero L. Cavalleri; Nic J. A. van der Wee; Andrew M. McIntosh; Randy L. Gollub; Kazima Bulayeva; Manon Bernard; Jennifer S. Richards; Jayandra J. Himali; Markus Loeffler; Nanda Rommelse; Wolfgang Hoffmann; Lars T. Westlye; Maria C. Valdés Hernández; Narelle K. Hansell; Theo G.M. van Erp; Christiane Wolf; John B. Kwok; Bruno Vellas; Andreas Heinz; Loes M. Olde Loohuis; Norman Delanty; Beng‐Choon Ho; Christopher R. K. Ching; Alena Shumskaya; Baljeet Singh; Albert Hofman; Dennis van der Meer; Georg Homuth; Bruce M. Psaty; Mark E. Bastin; Grant W. Montgomery; Tatiana Foroud; Simone Reppermund; Jouke‐Jan Hottenga; Andrew Simmons; Andreas Meyer‐Lindenberg; Wiepke Cahn; Christopher D. Whelan; Marjolein M. J. van Donkelaar; Qiong Yang; Norbert Hosten; Robert C. Green; Anbupalam Thalamuthu; Sebastian Mohnke; Hilleke E. Hulshoff Pol; Honghuang Lin; Clifford R. Jack; Peter R. Schofield; Thomas W. Mühleisen; Pauline Maillard; Steven G. Potkin; Wei Wen; Evan Fletcher; Arthur W. Toga; Oliver Gruber; Matthew J. Huentelman; George Davey Smith; Lenore J. Launer; Lars Nyberg; Erik G. Jönsson; Benedicto Crespo‐Facorro; Nastassja Koen; Douglas N. Greve; André G. Uitterlinden; Daniel R. Weinberger; Vidar M. Steen; Iryna O. Fedko; Nynke A. Groenewold; Wiro J. Niessen; Roberto Toro; Christophe Tzourio; W.T. Longstreth; Muhammad Ikram; Jordan W. Smoller; Marie‐José van Tol; Jessika E. Sussmann; Tomáš Paus; Hervé Lemaître; M. Schroeter; Bernard Mazoyer; Ole A. Andreassen; Florian Holsboer; Chantal Depondt; Dick J. Veltman; Jessica A. Turner; Zdenka Pausová; Günter Schumann; Daan van Rooij; Srdjan Djurovic; Ian J. Deary; Katie L. McMahon; Bertram Müller-Myhsok; Rachel M. Brouwer; Hilkka Soininen; Massimo Pandolfo; Thomas H. Wassink; J. Cheung; Thomas Wolfers; Jean-Luc Martinot; Marcel P. Zwiers; Matthias Nauck; Ingrid Melle; Nicholas G. Martin; Ryota Kanai; Eric Westman; René S. Kahn; Sanjay M. Sisodiya; Tonya White; Arvin Saremi; Hans van Bokhoven; Han G. Brunner; Henry Völzke; Margaret J. Wright; Dennis van ‘t Ent; Markus M. Nöthen; Roel A. Ophoff; Jan K. Buitelaar; Guillén Fernández; Perminder S. Sachdev; Marcella Rietschel; Neeltje E.M. van Haren; Simon E. Fisher; Alexa Beiser; Clyde Francks; Andrew J. Saykin; Karen A. Mather; Nina Romanczuk‐Seiferth; Catharina A. Hartman; Anita L. DeStefano; Dirk J. Heslenfeld; Michael Weiner; Henrik Walter; Pieter J. Hoekstra; Paul Nyquist; Barbara Franke; David A. Bennett; Hans J. Grabe; Andrew D. Johnson; Christopher Chen; Cornelia M. van Duijn; Oscar L. Lopez; Myriam Fornage; Joanna M. Wardlaw; Reinhold Schmidt; Charles DeCarli; Philip L. De Jager; Arno Villringer; Stéphanie Debette; Vilmundur Guðnason; Sarah E. Medland; Joshua Shulman; Paul M. Thompson; Sudha Seshadri; M. Arfan Ikram

doi:10.1038/s41588-019-0511-y

Genetic architecture of subcortical brain structures in 38,851 individuals

Claudia L. Satizábal(Boston University), Hieab H.H. Adams(Erasmus MC), Derrek P. Hibar(University of Southern California), Charles C. White(Broad Institute), Maria J. Knol(Erasmus MC), Jason L. Stein(University of North Carolina at Chapel Hill), Markus Scholz(Leipzig University), Muralidharan Sargurupremraj(Université de Bordeaux), Neda Jahanshad(University of Southern California), Gennady V. Roshchupkin(Erasmus MC), Albert V. Smith(University of Iceland), Joshua C. Bis(University of Washington), Xueqiu Jian(Brown Foundation), Michelle Luciano(University of Edinburgh), Edith Hofer(Medical University of Graz), Alexander Teumer(Universitätsmedizin Greifswald), Sven J. van der Lee(Erasmus MC), Jingyun Yang(Rush University Medical Center), Lisa R. Yanek(Johns Hopkins University), Tom V. Lee(Baylor College of Medicine), Shuo Li(Boston University), Yanhui Hu(Harvard University), Jia Yu Koh(Singapore National Eye Center), John D. Eicher(National Heart Lung and Blood Institute), Sylvane Desrivières(King's College London), Alejandro Arias Vásquez(Radboud University Nijmegen), Ganesh Chauhan(Université de Bordeaux), Lavinia Athanasiu(Oslo University Hospital), Miguel E. Rentería(QIMR Berghofer Medical Research Institute), Sung Eun Kim(Indiana University School of Medicine), David Hoehn(Max Planck Institute of Psychiatry), Nicola J. Armstrong(Murdoch University), Qiang Chen(Lieber Institute for Brain Development), Avram J. Holmes(Yale University), Anouk den Braber(Amsterdam Neuroscience), Iwona Kłoszewska(Medical University of Lodz), Micael Andersson(Umeå University), Thomas Espeseth(Oslo University Hospital), O. Grimm(Heidelberg University), Lucija Abramovic(Utrecht University), Saud Alhusaini(Royal College of Surgeons in Ireland), Yuri Milaneschi(Amsterdam Neuroscience), Martina Papmeyer(University of Bern), Tomas Axelsson(Uppsala University), Stefan Ehrlich(Massachusetts General Hospital), Roberto Roiz‐Santiáñez(Universidad de Cantabria), Bernd Kraemer(Heidelberg University), Asta K. Håberg(Norwegian University of Science and Technology), Hannah Jones(University Hospitals Bristol NHS Foundation Trust), G. Bruce Pike(University of Calgary), Dan J. Stein(South African Medical Research Council), Allison Stevens(Massachusetts General Hospital), Janita Bralten(Radboud University Nijmegen), Meike W. Vernooij(Erasmus MC), Tamara B. Harris(National Institutes of Health), Irina Filippi(Inserm), A. Veronica Witte(Max Planck Institute for Human Cognitive and Brain Sciences), Tulio Guadalupe(Max Planck Institute for Psycholinguistics), Katharina Wittfeld(Universitätsmedizin Greifswald), Thomas H. Mosley(Jackson Memorial Hospital), James T. Becker(University of Pittsburgh), Nhat Trung Doan(University of Oslo), Saskia P. Hagenaars(University of Edinburgh), Yasaman Saba(Medical University of Graz), Gabriel Cuéllar-Partida(QIMR Berghofer Medical Research Institute), Najaf Amin(Erasmus MC), Saima Hilal(National University of Singapore), Kwangsik Nho(Indiana University School of Medicine), Nazanin Mirza‐Schreiber(Helmholtz Zentrum München), Konstantinos Arfanakis(Rush University Medical Center), Diane M. Becker(Johns Hopkins University), David Ames(The Royal Melbourne Hospital), Aaron L. Goldman(Lieber Institute for Brain Development), Phil Hyu Lee(Broad Institute), Dorret I. Boomsma(Amsterdam Neuroscience), Simon Lovestone(King's College London), Sudheer Giddaluru(Haukeland University Hospital), Stéphanie Le Hellard(Haukeland University Hospital), Manuel Mattheisen(Aarhus University), Marc M. Bohlken(Utrecht University), Dalia Kasperavičiūtė(National Hospital for Neurology and Neurosurgery), Lianne Schmaal(The University of Melbourne), Stephen M. Lawrie(Royal Edinburgh Hospital), Ingrid Agartz(University of Oslo), Esther Walton(University of Bath), Diana Tordesillas‐Gutiérrez(Centro de Investigación Biomédica en Red de Salud Mental), Gareth E. Davies(Avera Health), Jean Shin(University of Toronto), Jonathan Ipser(University of Cape Town), Louis Vinke(Boston University), Martine Hoogman(Radboud University Nijmegen), Tianye Jia(King's College London), Ralph Burkhardt(University Hospital Regensburg), Marieke Klein(Radboud University Nijmegen), Fabrice Crivello(Centre National de la Recherche Scientifique), Deborah Janowitz(Universitätsmedizin Greifswald), Owen Carmichael(Pennington Biomedical Research Center), Unn K. Haukvik(Oslo University Hospital), Benjamin S. Aribisala(Lagos State University), Helena Schmidt(Medical University of Graz), Lachlan T. Strike(The University of Queensland), Ching‐Yu Cheng(Singapore National Eye Center), Shannon L. Risacher(Indiana University School of Medicine), Benno Pütz(Max Planck Institute of Psychiatry), Debra Fleischman(Rush University Medical Center), Amelia A. Assareh(UNSW Sydney), Venkata S. Mattay(Johns Hopkins University), Randy L. Buckner(Harvard University), Patrizia Mecocci(University of Perugia), Anders M. Dale(University of San Diego), Sven Cichon(University of Bonn), Marco P. Boks(Utrecht University), Mar Matarín(National Hospital for Neurology and Neurosurgery), Brenda W.J.H. Penninx(Amsterdam Neuroscience), Vince D. Calhoun(Mind Research Network), M. Mallar Chakravarty(Douglas Mental Health University Institute), André F. Marquand(Radboud University Nijmegen), Christine Macare(King's College London), Shahrzad Kharabian Masouleh(Forschungszentrum Jülich), Jaap Oosterlaan(Emma Kinderziekenhuis), Philippe Amouyel(Inserm), Katrin Hegenscheid(Universitätsmedizin Greifswald), Jerome I. Rotter(The Lundquist Institute), Andrew J. Schork(Translational Genomics Research Institute), David C. Liewald(University of Edinburgh), Greig I. de Zubicaray(Queensland University of Technology), Tien Yin Wong(Singapore National Eye Center), Li Shen(University of Pennsylvania), Philipp G. Sämann(Max Planck Institute of Psychiatry), Henry Brodaty(UNSW Sydney), Joshua L. Roffman(Massachusetts General Hospital), Eco J. C. de Geus(Amsterdam Neuroscience), Magda Tsolaki(Aristotle University of Thessaloniki), Susanne Erk(Humboldt-Universität zu Berlin), Kristel R. van Eijk(University Medical Center Utrecht), Gianpiero L. Cavalleri(Royal College of Surgeons in Ireland), Nic J. A. van der Wee(Leiden University Medical Center), Andrew M. McIntosh(Royal Edinburgh Hospital), Randy L. Gollub(Harvard University), Kazima Bulayeva(Dagestan State University), Manon Bernard(University of Toronto), Jennifer S. Richards(University Medical Center Groningen), Jayandra J. Himali(Boston University), Markus Loeffler(Leipzig University), Nanda Rommelse(Radboud University Nijmegen), Wolfgang Hoffmann(Universitätsmedizin Greifswald), Lars T. Westlye(Oslo University Hospital), Maria C. Valdés Hernández(University of Edinburgh), Narelle K. Hansell(The University of Queensland), Theo G.M. van Erp(University of California, Irvine), Christiane Wolf(University of Würzburg), John B. Kwok(The University of Sydney), Bruno Vellas(Inserm), Andreas Heinz(Charité - Universitätsmedizin Berlin), Loes M. Olde Loohuis(University of California, Los Angeles), Norman Delanty(Royal College of Surgeons in Ireland), Beng‐Choon Ho(University of Iowa), Christopher R. K. Ching(University of Southern California), Alena Shumskaya(Radboud University Nijmegen), Baljeet Singh(University of California, Davis), Albert Hofman(Harvard University), Dennis van der Meer(Oslo University Hospital), Georg Homuth(Universitätsmedizin Greifswald), Bruce M. Psaty(Kaiser Permanente Washington Health Research Institute), Mark E. Bastin(University of Edinburgh), Grant W. Montgomery(The University of Queensland), Tatiana Foroud(Indiana University School of Medicine), Simone Reppermund(UNSW Sydney), Jouke‐Jan Hottenga(Amsterdam Neuroscience), Andrew Simmons(King's College London), Andreas Meyer‐Lindenberg(Heidelberg University), Wiepke Cahn(Utrecht University), Christopher D. Whelan(University of Southern California), Marjolein M. J. van Donkelaar(Radboud University Nijmegen), Qiong Yang(Boston University), Norbert Hosten(Universitätsmedizin Greifswald), Robert C. Green(Brigham and Women's Hospital), Anbupalam Thalamuthu(UNSW Sydney), Sebastian Mohnke(Humboldt-Universität zu Berlin), Hilleke E. Hulshoff Pol(Utrecht University), Honghuang Lin(Boston University), Clifford R. Jack(Mayo Clinic in Arizona), Peter R. Schofield(UNSW Sydney), Thomas W. Mühleisen(University of Basel), Pauline Maillard(University of California, Davis), Steven G. Potkin(University of California, Irvine), Wei Wen(UNSW Sydney), Evan Fletcher(University of California, Davis), Arthur W. Toga(University of Southern California), Oliver Gruber(Heidelberg University), Matthew J. Huentelman(Translational Genomics Research Institute), George Davey Smith(University of Bristol), Lenore J. Launer(National Institutes of Health), Lars Nyberg(Umeå University), Erik G. Jönsson(University of Oslo), Benedicto Crespo‐Facorro(Universidad de Cantabria), Nastassja Koen(South African Medical Research Council), Douglas N. Greve(Harvard University), André G. Uitterlinden(Erasmus MC), Daniel R. Weinberger(Johns Hopkins University), Vidar M. Steen(Haukeland University Hospital), Iryna O. Fedko(Vrije Universiteit Amsterdam), Nynke A. Groenewold(University of Cape Town), Wiro J. Niessen(Erasmus MC), Roberto Toro(Universidad de Cantabria), Christophe Tzourio(Centre Hospitalier Universitaire de Bordeaux), W.T. Longstreth(University of Washington), Muhammad Ikram(Erasmus MC), Jordan W. Smoller(Broad Institute), Marie‐José van Tol(University Medical Center Groningen), Jessika E. Sussmann(Royal Edinburgh Hospital), Tomáš Paus(University of Toronto), Hervé Lemaître(Inserm), M. Schroeter(University Hospital Leipzig), Bernard Mazoyer(Centre National de la Recherche Scientifique), Ole A. Andreassen(Oslo University Hospital), Florian Holsboer(HolsboerMaschmeyer NeuroChemie (Germany)), Chantal Depondt(Université Libre de Bruxelles), Dick J. Veltman(Amsterdam Neuroscience), Jessica A. Turner(Mind Research Network), Zdenka Pausová(University of Toronto), Günter Schumann(King's College London), Daan van Rooij(University Medical Center Groningen), Srdjan Djurovic(Oslo University Hospital), Ian J. Deary(University of Edinburgh), Katie L. McMahon(Queensland University of Technology), Bertram Müller-Myhsok(University of Liverpool), Rachel M. Brouwer(Utrecht University), Hilkka Soininen(University of Eastern Finland), Massimo Pandolfo(Université Libre de Bruxelles), Thomas H. Wassink(University of Iowa), J. Cheung(University of Southern California), Thomas Wolfers(Radboud University Nijmegen), Jean-Luc Martinot(Inserm), Marcel P. Zwiers(Radboud University Nijmegen), Matthias Nauck(Universitätsmedizin Greifswald), Ingrid Melle(Oslo University Hospital), Nicholas G. Martin(QIMR Berghofer Medical Research Institute), Ryota Kanai(University of Sussex), Eric Westman(Karolinska Institutet), René S. Kahn(Utrecht University), Sanjay M. Sisodiya(National Hospital for Neurology and Neurosurgery), Tonya White(Erasmus MC), Arvin Saremi(University of Southern California), Hans van Bokhoven(Radboud University Nijmegen), Han G. Brunner(Radboud University Nijmegen), Henry Völzke(Universitätsmedizin Greifswald), Margaret J. Wright(The University of Queensland), Dennis van ‘t Ent(Amsterdam Neuroscience), Markus M. Nöthen(University of Bonn), Roel A. Ophoff(University of California, Los Angeles), Jan K. Buitelaar(Radboud University Nijmegen), Guillén Fernández(Radboud University Nijmegen), Perminder S. Sachdev(UNSW Sydney), Marcella Rietschel(Heidelberg University), Neeltje E.M. van Haren(Utrecht University), Simon E. Fisher(Radboud University Nijmegen), Alexa Beiser(Boston University), Clyde Francks(Radboud University Nijmegen), Andrew J. Saykin(Indiana University School of Medicine), Karen A. Mather(UNSW Sydney), Nina Romanczuk‐Seiferth(Charité - Universitätsmedizin Berlin), Catharina A. Hartman(University Medical Center Groningen), Anita L. DeStefano(Boston University), Dirk J. Heslenfeld(Vrije Universiteit Amsterdam), Michael Weiner(San Francisco VA Medical Center), Henrik Walter(Humboldt-Universität zu Berlin), Pieter J. Hoekstra(University Medical Center Groningen), Paul Nyquist(Johns Hopkins University), Barbara Franke(Radboud University Nijmegen), David A. Bennett(Rush University Medical Center), Hans J. Grabe(Universitätsmedizin Greifswald), Andrew D. Johnson(National Heart Lung and Blood Institute), Christopher Chen(National University of Singapore), Cornelia M. van Duijn(Leiden University), Oscar L. Lopez(University of Pittsburgh), Myriam Fornage(Brown Foundation), Joanna M. Wardlaw(UK Dementia Research Institute), Reinhold Schmidt(Medical University of Graz), Charles DeCarli(University of California, Davis), Philip L. De Jager(Broad Institute), Arno Villringer(Max Planck Institute for Human Cognitive and Brain Sciences), Stéphanie Debette(Boston University), Vilmundur Guðnason(University of Iceland), Sarah E. Medland(QIMR Berghofer Medical Research Institute), Joshua Shulman(Baylor College of Medicine), Paul M. Thompson(University of Southern California), Sudha Seshadri(Boston University), M. Arfan Ikram(Erasmus MC)

Nature Genetics

October 21, 2019

10.1038/s41588-019-0511-y

Cited by 286Open Access

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