Novel Plasmid-Mediated <i>tet</i> (X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate

Liyuan Wang(Peking University), Dejun Liu(China Agricultural University), Yuan Lv(Peking University), Lanqing Cui(Peking University), Yun Li(Peking University), Tianmeng Li(Peking University), Huangwei Song(China Agricultural University), Yuxin Hao(China Agricultural University), Jianzhong Shen(China Agricultural University), Yang Wang(China Agricultural University), Timothy R. Walsh(Centre for Immunity, Infection and Evolution)
Antimicrobial Agents and Chemotherapy
October 10, 2019
10.1128/aac.01326-19
Cited by 171Open Access
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Abstract

A novel, plasmid-mediated, high-level tigecycline resistance tet (X) gene variant, tet (X5), was detected in a clinical Acinetobacter baumannii isolate from China in 2017. Tet(X5) shows 84.5% and 90.5% amino acid identity to Tet(X3) and Tet(X4), respectively, with similar binding sites and a comparable affinity for tetracyclines. The tet (X5)-containing plasmid could only be transferred to A. baumannii via electrotransformation.

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