Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

German Chronic Kidney Disease Study; Adrienne Tin; Lifelines Cohort Study; V. A. Million Veteran Program; Jonathan Marten; Victoria L. Halperin Kuhns; Yong Li; Matthias Wuttke; Holger Kirsten; Karsten B. Sieber; Chengxiang Qiu; Mathias Gorski; Zhi Yu; Ayush Giri; Garðar Sveinbjörnsson; Man Li; Audrey Y. Chu; Anselm Hoppmann; Luke J. O’Connor; Bram P. Prins; Teresa Nutile; Damia Noce; Masato Akiyama; Massimiliano Cocca; Sahar Ghasemi; Peter J. van der Most; Katrin Horn; Yizhe Xu; Christian Fuchsberger; Sanaz Sedaghat; Saima Afaq; Najaf Amin; Johan Ärnlöv; Stephan J. L. Bakker; Nisha Bansal; Daniela Baptista; Sven Bergmann; Mary L. Biggs; Ginevra Biino; Eric Boerwinkle; Erwin P. Böttinger; Thibaud Boutin; Marco Brumat; Ralph Burkhardt; Eric Campana; Archie Campbell; Harry Campbell; Robert J. Carroll; Eulalia Catamo; John C. Chambers; Marina Ciullo; Maria Pina Concas; Josef Coresh; Tanguy Corre; Daniele Cusi; Cinzia Sala; Martin H. de Borst; Alessandro De Grandi; Renée de Mutsert; Aiko P. J. de Vries; Graciela Delgado; Ayşe Demirkan; Olivier Devuyst; Katalin Dittrich; Kai‐Uwe Eckardt; Georg Ehret; Karlhans Endlich; Michele K. Evans; Ron T. Gansevoort; Paolo Gasparini; Vilmantas Giedraitis; Christian Gieger; Giorgia Girotto; Martin Gögele; Scott D. Gordon; Daníel F. Guðbjartsson; Vilmundur Guðnason; Toomas Haller; Pavel Hamet; Tamara B. Harris; Caroline Hayward; Andrew A. Hicks; Edith Hofer; Hilma Hólm; Wei Huang; Nina Hutri‐Kähönen; Shih‐Jen Hwang; M. Arfan Ikram; Raychel M. Lewis; Erik Ingelsson; Jóhanna Jakobsdóttir; Ingileif Jónsdóttir; Helgi Jónsson; Peter K. Joshi; Navya Shilpa Josyula; Bettina Jung; Mika Kähönen; Yoichiro Kamatani; Masahiro Kanai; Shona M. Kerr; Wieland Kieß; Marcus E. Kleber; Wolfgang Köenig; Jaspal S. Kooner; Antje Körner; Péter Kovács; Bernhard K. Krämer; Florian Kronenberg; Michiaki Kubo; Brigitte Kühnel; Martina La Bianca; Leslie A. Lange; Benjamin Lehne; Terho Lehtimäki; Jun Liu; Markus Loeffler; Ruth J. F. Loos; Leo‐Pekka Lyytikäinen; Reedik Mägi; Anubha Mahajan; Nicholas G. Martin; Winfried März; Deborah Mascalzoni; Koichi Matsuda; Christa Meisinger; Thomas Meitinger; Andres Metspalu; Yuri Milaneschi; Christopher J. O’Donnell; Otis D. Wilson; J. Michael Gaziano; Pashupati P. Mishra; Karen L. Mohlke; Nina Mononen; Grant W. Montgomery; Dennis O. Mook‐Kanamori; Martina Müller‐Nurasyid; Girish N. Nadkarni; Mike A. Nalls; Matthias Nauck; Kjell Nikus; Boting Ning; Ilja M. Nolte; Raymond Noordam; Jeffrey R. O’Connell; Ísleifur Ólafsson; Sandosh Padmanabhan; Brenda W.J.H. Penninx; Thomas T. Perls; Annette Peters; Mario Pirastu; Nicola Pirastu; Giorgio Pistis; Ozren Polašek; Belén Ponte; David J. Porteous; Tanja Poulain; Michael Preuß; Ton J. Rabelink; Laura M. Raffield; Olli T. Raitakari; Rainer Rettig; Myriam Rheinberger; Kenneth Rice; Federica Rizzi; Antonietta Robino; Igor Rudan; Alena Krajčoviechová; Renata Cífková; Rico Rueedi; Daniela Ruggiero; Kathleen A. Ryan; Yasaman Saba; Erika Salvi; Helena Schmidt; Reinhold Schmidt; Christian M. Shaffer; Albert V. Smith; Blair H. Smith; Cassandra N. Spracklen; Konstantin Strauch; Michael Stümvoll; Patrick Sulem; Salman M. Tajuddin; Andrej Teren; Joachim Thiery; Chris H. L. Thio; Unnur Þorsteinsdóttir; Daniela Toniolo; Anke Tönjes; Johanne Tremblay; André G. Uitterlinden; Simona Vaccargiu; Pim van der Harst; Cornelia M. van Duijn; Niek Verweij; Uwe Völker; Péter Vollenweider; Gérard Waeber; Mélanie Waldenberger; John B. Whitfield; Sarah H. Wild; James F. Wilson; Qiong Yang; Weihua Zhang; Alan B. Zonderman; Murielle Bochud; James G. Wilson; Sarah A. Pendergrass; Kevin Ho; Afshin Parsa; Peter P. Pramstaller; Bruce M. Psaty; Carsten A. Böger; Harold Snieder; Adam S. Butterworth; Yukinori Okada; Todd L. Edwards; Kāri Stefánsson; Katalin Suszták; Markus Scholz; Iris M. Heid; Adriana M. Hung; Alexander Teumer; Cristian Pattaro; Owen M. Woodward; Véronique Vitart; Anna Köttgen

doi:10.1038/s41588-019-0504-x

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

German Chronic Kidney Disease Study(Johns Hopkins University), Adrienne Tin(Johns Hopkins University), Lifelines Cohort Study(University of Maryland, Baltimore), V. A. Million Veteran Program(University of Freiburg), Jonathan Marten(University of Freiburg), Victoria L. Halperin Kuhns(University of Maryland, Baltimore), Yong Li(Target (United States)), Matthias Wuttke(University of Freiburg), Holger Kirsten(University Hospital Regensburg), Karsten B. Sieber(Johns Hopkins University), Chengxiang Qiu(University of Pennsylvania), Mathias Gorski(deCODE Genetics (Iceland)), Zhi Yu(Johns Hopkins University), Ayush Giri(Merck & Co., Inc., Rahway, NJ, USA (United States)), Garðar Sveinbjörnsson(deCODE Genetics (Iceland)), Man Li(Harvard University), Audrey Y. Chu(Merck & Co., Inc., Rahway, NJ, USA (United States)), Anselm Hoppmann(University of Freiburg), Luke J. O’Connor(Eurac Research), Bram P. Prins(University of Cambridge), Teresa Nutile(IRCCS Materno Infantile Burlo Garofolo), Damia Noce(Eurac Research), Masato Akiyama(University Medical Center Groningen), Massimiliano Cocca(IRCCS Materno Infantile Burlo Garofolo), Sahar Ghasemi(University of Utah), Peter J. van der Most(Eurac Research), Katrin Horn(Erasmus MC), Yizhe Xu(University of Utah), Christian Fuchsberger(Eurac Research), Sanaz Sedaghat(Erasmus MC), Saima Afaq(University Medical Center Groningen), Najaf Amin(University of Washington), Johan Ärnlöv(Dalarna University), Stephan J. L. Bakker(University Medical Center Groningen), Nisha Bansal(University of Washington), Daniela Baptista(University Hospital of Geneva), Sven Bergmann(SIB Swiss Institute of Bioinformatics), Mary L. Biggs(University of Washington), Ginevra Biino(National Research Council), Eric Boerwinkle(University of Trieste), Erwin P. Böttinger(Icahn School of Medicine at Mount Sinai), Thibaud Boutin(University of Trieste), Marco Brumat(University of Trieste), Ralph Burkhardt(University Hospital Regensburg), Eric Campana(University of Trieste), Archie Campbell(IRCCS Materno Infantile Burlo Garofolo), Harry Campbell(Imperial College London), Robert J. Carroll(Institute of Genetics and Biophysics), Eulalia Catamo(IRCCS Materno Infantile Burlo Garofolo), John C. Chambers(Johns Hopkins University), Marina Ciullo(Istituto Neurologico Mediterraneo), Maria Pina Concas(IRCCS Materno Infantile Burlo Garofolo), Josef Coresh(Johns Hopkins University), Tanguy Corre(SIB Swiss Institute of Bioinformatics), Daniele Cusi(Eurac Research), Cinzia Sala(Leiden University Medical Center), Martin H. de Borst(Leiden University), Alessandro De Grandi(Eurac Research), Renée de Mutsert(Leiden University Medical Center), Aiko P. J. de Vries(Leiden University), Graciela Delgado(Heidelberg University), Ayşe Demirkan(University Medical Center Groningen), Olivier Devuyst(University of Zurich), Katalin Dittrich(Leipzig University of Applied Sciences), Kai‐Uwe Eckardt(National Institutes of Health), Georg Ehret(University Medical Center Groningen), Karlhans Endlich(Universitätsmedizin Greifswald), Michele K. Evans(Uppsala University), Ron T. Gansevoort(University Medical Center Groningen), Paolo Gasparini(University of Trieste), Vilmantas Giedraitis(Uppsala University), Christian Gieger(QIMR Berghofer Medical Research Institute), Giorgia Girotto(deCODE Genetics (Iceland)), Martin Gögele(Eurac Research), Scott D. Gordon(QIMR Berghofer Medical Research Institute), Daníel F. Guðbjartsson(deCODE Genetics (Iceland)), Vilmundur Guðnason(National Institutes of Health), Toomas Haller(Institute of Genetics and Cancer), Pavel Hamet(Eurac Research), Tamara B. Harris(National Institutes of Health), Caroline Hayward(deCODE Genetics (Iceland)), Andrew A. Hicks(Eurac Research), Edith Hofer(Tampere University), Hilma Hólm(deCODE Genetics (Iceland)), Wei Huang(Chinese National Human Genome Center), Nina Hutri‐Kähönen(University of Maryland, Baltimore), Shih‐Jen Hwang(National Heart Lung and Blood Institute), M. Arfan Ikram(Erasmus MC), Raychel M. Lewis(University of Maryland, Baltimore), Erik Ingelsson(Uppsala University), Jóhanna Jakobsdóttir(University of Iceland), Ingileif Jónsdóttir(deCODE Genetics (Iceland)), Helgi Jónsson(University of Iceland), Peter K. Joshi(Tampere University Hospital), Navya Shilpa Josyula(RIKEN Center for Integrative Medical Sciences), Bettina Jung(University Hospital Regensburg), Mika Kähönen(Tampere University Hospital), Yoichiro Kamatani(Kyoto University), Masahiro Kanai(Harvard University), Shona M. Kerr(Deutsches Herzzentrum München), Wieland Kieß(Leipzig University of Applied Sciences), Marcus E. Kleber(Heidelberg University), Wolfgang Köenig(Universität Ulm), Jaspal S. Kooner(Imperial College Healthcare NHS Trust), Antje Körner(Innsbruck Medical University), Péter Kovács(IFB Adiposity Diseases), Bernhard K. Krämer(Heidelberg University), Florian Kronenberg(Innsbruck Medical University), Michiaki Kubo(RIKEN Center for Integrative Medical Sciences), Brigitte Kühnel(Helmholtz Zentrum München), Martina La Bianca(Tampere University), Leslie A. Lange(Erasmus MC), Benjamin Lehne(Imperial College London), Terho Lehtimäki(Tampere University), Jun Liu(Tampere University), Markus Loeffler(University of Tartu), Ruth J. F. Loos(Centre for Human Genetics), Leo‐Pekka Lyytikäinen(Tampere University), Reedik Mägi(Heidelberg University), Anubha Mahajan(Eurac Research), Nicholas G. Martin(QIMR Berghofer Medical Research Institute), Winfried März(Medical University of Graz), Deborah Mascalzoni(Eurac Research), Koichi Matsuda(University of Tartu), Christa Meisinger(University of Augsburg), Thomas Meitinger(VA Boston Healthcare System), Andres Metspalu(University of Tartu), Yuri Milaneschi(Brigham and Women's Hospital), Christopher J. O’Donnell(Tampere University), Otis D. Wilson(University of North Carolina at Chapel Hill), J. Michael Gaziano(Brigham and Women's Hospital), Pashupati P. Mishra(The University of Queensland), Karen L. Mohlke(University of North Carolina at Chapel Hill), Nina Mononen(Tampere University), Grant W. Montgomery(The University of Queensland), Dennis O. Mook‐Kanamori(Leiden University), Martina Müller‐Nurasyid(Helmholtz Zentrum München), Girish N. Nadkarni(Tampere University Hospital), Mike A. Nalls(Boston University), Matthias Nauck(University Medical Center Groningen), Kjell Nikus(Leiden University), Boting Ning(Boston University), Ilja M. Nolte(Reykjavík University), Raymond Noordam(Leiden University), Jeffrey R. O’Connell(Amsterdam Neuroscience), Ísleifur Ólafsson(Boston University), Sandosh Padmanabhan(Helmholtz Zentrum München), Brenda W.J.H. Penninx(Amsterdam Neuroscience), Thomas T. Perls(Boston University), Annette Peters(University Hospital of Lausanne), Mario Pirastu(Institute of Genetic and Biomedical Research), Nicola Pirastu(University Hospital of Geneva), Giorgio Pistis(University Hospital of Lausanne), Ozren Polašek(University of Split), Belén Ponte(University Hospital of Geneva), David J. Porteous(Leiden University), Tanja Poulain(University of North Carolina at Chapel Hill), Michael Preuß(Turku University Hospital), Ton J. Rabelink(Leiden University), Laura M. Raffield(University of North Carolina at Chapel Hill), Olli T. Raitakari(University of Turku), Rainer Rettig(University of Milan), Myriam Rheinberger(IRCCS Materno Infantile Burlo Garofolo), Kenneth Rice(University of Washington), Federica Rizzi(University of Milan), Antonietta Robino(Charles University), Igor Rudan(SIB Swiss Institute of Bioinformatics), Alena Krajčoviechová(Charles University), Renata Cífková(University of Maryland, Baltimore), Rico Rueedi(SIB Swiss Institute of Bioinformatics), Daniela Ruggiero(University of Milan), Kathleen A. Ryan(University of Maryland, Baltimore), Yasaman Saba(Medical University of Graz), Erika Salvi(University of Milan), Helena Schmidt(University of Iceland), Reinhold Schmidt(University of Dundee), Christian M. Shaffer(University of North Carolina at Chapel Hill), Albert V. Smith(University of Iceland), Blair H. Smith(University of Dundee), Cassandra N. Spracklen(University of North Carolina at Chapel Hill), Konstantin Strauch(National Institutes of Health), Michael Stümvoll(Leipzig Heart Institute), Patrick Sulem(deCODE Genetics (Iceland)), Salman M. Tajuddin(National Institutes of Health), Andrej Teren(deCODE Genetics (Iceland)), Joachim Thiery(San Raffaele University of Rome), Chris H. L. Thio(University Medical Center Groningen), Unnur Þorsteinsdóttir(deCODE Genetics (Iceland)), Daniela Toniolo(Erasmus MC), Anke Tönjes(Institute of Genetic and Biomedical Research), Johanne Tremblay(University Medical Center Groningen), André G. Uitterlinden(Erasmus MC), Simona Vaccargiu(University Medical Center Groningen), Pim van der Harst(University Medical Center Groningen), Cornelia M. van Duijn(Leiden University), Niek Verweij(University Medical Center Groningen), Uwe Völker(Universitätsmedizin Greifswald), Péter Vollenweider(QIMR Berghofer Medical Research Institute), Gérard Waeber(Glasgow Centre for Population Health), Mélanie Waldenberger(Helmholtz Zentrum München), John B. Whitfield(Boston University), Sarah H. Wild(Ealing Hospital), James F. Wilson(National Institutes of Health), Qiong Yang(Boston University), Weihua Zhang(Ealing Hospital), Alan B. Zonderman(National Institutes of Health), Murielle Bochud(Centre universitaire de médecine générale et santé publique, Lausanne), James G. Wilson(National Institutes of Health), Sarah A. Pendergrass(Eurac Research), Kevin Ho(Geisinger Medical Center), Afshin Parsa(University of Maryland, Baltimore), Peter P. Pramstaller(Eurac Research), Bruce M. Psaty(Kaiser Permanente Washington Health Research Institute), Carsten A. Böger(University Hospital Regensburg), Harold Snieder(University Medical Center Groningen), Adam S. Butterworth(deCODE Genetics (Iceland)), Yukinori Okada(RIKEN Center for Integrative Medical Sciences), Todd L. Edwards(Vanderbilt University), Kāri Stefánsson(deCODE Genetics (Iceland)), Katalin Suszták(University of Pennsylvania), Markus Scholz(German Centre for Cardiovascular Research), Iris M. Heid(Eurac Research), Adriana M. Hung(University of Maryland, Baltimore), Alexander Teumer(Universitätsmedizin Greifswald), Cristian Pattaro(Eurac Research), Owen M. Woodward(University of Maryland, Baltimore), Véronique Vitart(Institute of Genetics and Cancer), Anna Köttgen(Johns Hopkins University)

Nature Genetics

October 1, 2019

10.1038/s41588-019-0504-x

Cited by 427Open Access

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