Conjugative Delivery of CRISPR-Cas9 for the Selective Depletion of Antibiotic-Resistant Enterococci
Marinelle Rodrigues(The University of Texas at Dallas), Sara W. McBride(University of Colorado Denver), Karthik Hullahalli(The University of Texas at Dallas), Kelli L. Palmer(The University of Texas at Dallas), Breck A. Duerkop(University of Colorado Denver)
Cited by 154Open Access
Abstract
The innovation of new therapies to combat multidrug-resistant (MDR) bacteria is being outpaced by the continued rise of MDR bacterial infections. Of particular concern are hospital-acquired infections (HAIs) that are recalcitrant to antibiotic therapies. The Gram-positive intestinal pathobiont Enterococcus faecalis is associated with HAIs, and some strains are MDR. Therefore, novel strategies to control E. faecalis populations are needed.
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