Model systems for regeneration: planarians
Mario Ivanković(Max Planck Institute of Molecular Cell Biology and Genetics), Radmila Haneckova(Max Planck Institute for Biophysical Chemistry), Albert Thommen(The Francis Crick Institute), Markus A. Grohme(Max Planck Institute of Molecular Cell Biology and Genetics), Miquel Vila‐Farré(Max Planck Institute for Biophysical Chemistry), Steffen Werner(Institute for Atomic and Molecular Physics), Jochen C. Rink(Max Planck Institute for Biophysical Chemistry)
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Abstract
Planarians are a group of flatworms. Some planarian species have remarkable regenerative abilities, which involve abundant pluripotent adult stem cells. This makes these worms a powerful model system for understanding the molecular and evolutionary underpinnings of regeneration. By providing a succinct overview of planarian taxonomy, anatomy, available tools and the molecular orchestration of regeneration, this Primer aims to showcase both the unique assets and the questions that can be addressed with this model system.
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