Comorbid and inflammatory characteristics of genetic subtypes of clonal hematopoiesis

Elina K. Cook; Terumi Izukawa; Sherylan Young; Gili Rosen; Mina Jamali; Liying Zhang; Dylan Johnson; Eva Bain; Jamie Hilland; Christina K. Ferrone; Jonah Buckstein; Janika Francis; Bushra Momtaz; Amy J. M. McNaughton; Xudong Liu; Brooke Snetsinger; Rena Buckstein; Michael J. Rauh

doi:10.1182/bloodadvances.2018024729

Comorbid and inflammatory characteristics of genetic subtypes of clonal hematopoiesis

Elina K. Cook(Queen's University), Terumi Izukawa(University of Toronto), Sherylan Young, Gili Rosen(Baycrest Hospital), Mina Jamali(Sunnybrook Health Science Centre), Liying Zhang(Sunnybrook Health Science Centre), Dylan Johnson(Queen's University), Eva Bain(Queen's University), Jamie Hilland(Queen's University), Christina K. Ferrone(Queen's University), Jonah Buckstein(Queen's University), Janika Francis(Sunnybrook Health Science Centre), Bushra Momtaz(Baycrest Hospital), Amy J. M. McNaughton(Queen's University), Xudong Liu(Queen's University), Brooke Snetsinger(Queen's University), Rena Buckstein(Sunnybrook Health Science Centre), Michael J. Rauh(Queen's University)

Blood Advances

August 21, 2019

10.1182/bloodadvances.2018024729

Cited by 147Open Access

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Abstract

Key Points CH may be associated with broader ill health (worse performance status, increased and potentially novel comorbidities). Serum interleukin-6 is elevated in people with CH and genetic subtypes, providing a view of the human systemic inflammatory landscape of CH.

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