Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

Yehezqel Elyahu; Idan Hekselman; Inbal Eizenberg-Magar; Omer Berner; Itai Strominger; Maya Schiller; Kritika Mittal; Anna Nemirovsky; Ekaterina Eremenko; Assaf Vital; Eyal Simonovsky; Vered Chalifa‐Caspi; Nir Friedman; Esti Yeger‐Lotem; Alon Monsonego

doi:10.1126/sciadv.aaw8330

Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

Yehezqel Elyahu(Ben-Gurion University of the Negev), Idan Hekselman(Ben-Gurion University of the Negev), Inbal Eizenberg-Magar(Weizmann Institute of Science), Omer Berner(Ben-Gurion University of the Negev), Itai Strominger(Ben-Gurion University of the Negev), Maya Schiller(Technion – Israel Institute of Technology), Kritika Mittal(Ben-Gurion University of the Negev), Anna Nemirovsky(Ben-Gurion University of the Negev), Ekaterina Eremenko(Ben-Gurion University of the Negev), Assaf Vital(Ben-Gurion University of the Negev), Eyal Simonovsky(Ben-Gurion University of the Negev), Vered Chalifa‐Caspi(Ben-Gurion University of the Negev), Nir Friedman(Weizmann Institute of Science), Esti Yeger‐Lotem(Ben-Gurion University of the Negev), Alon Monsonego(Ben-Gurion University of the Negev)

Science Advances

August 2, 2019

10.1126/sciadv.aaw8330

Cited by 322Open Access

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Abstract

, respectively. These findings provide a comprehensive view of the dynamic reorganization of the CD4 T cell milieu with age and illuminate dominant subsets associated with chronic inflammation and immunity decline, suggesting new therapeutic avenues for age-related diseases.

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