Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures
Yasir Elhassan(NIHR Birmingham Biomedical Research Centre), Katarína Kľučková(University of Birmingham), Rachel S. Fletcher(University of Birmingham), Mark S. Schmidt(University of Iowa), Antje Garten(University of Birmingham), Craig Doig(University of Birmingham), David M. Cartwright(University of Birmingham), Lucy Oakey(University of Birmingham), Claire V. Burley(Birmingham City University), Ned Jenkinson(Birmingham City University), Martin Wilson(Birmingham City University), Samuel J. E. Lucas(Birmingham City University), İldem Akerman(University of Birmingham), Alex P. Seabright(University of Birmingham), Yu‐Chiang Lai(University of Birmingham), Daniel A. Tennant(University of Birmingham), Peter Nightingale(University Hospitals Birmingham NHS Foundation Trust), Gareth A. Wallis(University of Birmingham), Konstantinos Manolopoulos(NIHR Birmingham Biomedical Research Centre), Charles Brenner(University of Iowa), Andrew Philp(Garvan Institute of Medical Research), Gareth G. Lavery(NIHR Birmingham Biomedical Research Centre)
Cited by 430Open Access
Abstract
metabolome, evident by increased nicotinic acid adenine dinucleotide and nicotinamide clearance products. Muscle RNA sequencing revealed NR-mediated downregulation of energy metabolism and mitochondria pathways, without altering mitochondrial bioenergetics. NR also depressed levels of circulating inflammatory cytokines. Our data establish that oral NR is available to aged human muscle and identify anti-inflammatory effects of NR.
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