Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model

Kim Anthony-Gonda; Ariola Bardhi; Alex Ray; Nina C. Flerin; Mengyan Li; Weizao Chen; Christina Ochsenbauer; John C. Kappes; Winfried Krueger; Andrew Worden; Dina Schneider; Zhongyu Zhu; Rimas J. Orentas; Dimiter S. Dimitrov; Harris Goldstein; Boro Dropulić

doi:10.1126/scitranslmed.aav5685

Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model

Kim Anthony-Gonda(Lentigen Technology (United States)), Ariola Bardhi(Albert Einstein College of Medicine), Alex Ray(Albert Einstein College of Medicine), Nina C. Flerin(Albert Einstein College of Medicine), Mengyan Li(Albert Einstein College of Medicine), Weizao Chen(National Institutes of Health), Christina Ochsenbauer(University of Alabama at Birmingham), John C. Kappes(University of Alabama at Birmingham), Winfried Krueger(Lentigen Technology (United States)), Andrew Worden(Lentigen Technology (United States)), Dina Schneider(Lentigen Technology (United States)), Zhongyu Zhu(Lentigen Technology (United States)), Rimas J. Orentas(Lentigen Technology (United States)), Dimiter S. Dimitrov(University of Pittsburgh), Harris Goldstein(Albert Einstein College of Medicine), Boro Dropulić(Lentigen Technology (United States))

Science Translational Medicine

August 7, 2019

10.1126/scitranslmed.aav5685

Cited by 160Open Access

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Abstract

T cells during HIV infection using a humanized NSG mouse model of intrasplenic HIV infection. These data suggest that multispecific anti-HIV duoCAR-T cells could be an effective approach for the treatment of patients with HIV-1 infection.

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