Nerve injury drives a heightened state of vigilance and neuropathic sensitization in <i>Drosophila</i>
Thang M. Khuong(The University of Sydney), Qiao‐Ping Wang(The University of Sydney), John Manion(The University of Sydney), Lisa J. Oyston(The University of Sydney), Man-Tat Lau(The University of Sydney), Harry Towler(The University of Sydney), Yong Lin(The University of Sydney), G. Gregory Neely(The University of Sydney)
Cited by 81Open Access
Abstract
and led to caspase-dependent death of GABAergic neurons. Conversely, disruption of GABA signaling was sufficient to trigger allodynia without injury. Last, we identified the conserved transcription factor twist as a critical downstream regulator driving GABAergic cell death and neuropathic allodynia. Together, we define how injury leads to allodynia in insects, and describe a primordial precursor to neuropathic pain may have been advantageous, protecting animals after serious injury.
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