Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

Irène Baccelli; Yves Gareau; Bernhard Lehnertz; Stéphane Gingras; Jean-François Spinella; Sophie Corneau; Nadine Mayotte; Simon Girard; Mélanie Fréchette; Valérie Blouin-Chagnon; Koryne Leveillé; Isabel Boivin; Tara MacRae; Jana Krošl; Clarisse Thiollier; Vincent‐Philippe Lavallée; Evgeny Kanshin; Thierry Bertomeu; Jasmin Coulombe‐Huntington; Corinne St‐Denis; Marie-Ève Bordeleau; Geneviève Boucher; Philippe P. Roux; Sébastien Lemieux; Mike Tyers; Pierre Thibault; Josée Hébert; Anne Marinier; Guy Sauvageau

doi:10.1016/j.ccell.2019.06.003

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

Irène Baccelli(Institute for Research in Immunology and Cancer), Yves Gareau(Institute for Research in Immunology and Cancer), Bernhard Lehnertz(Institute for Research in Immunology and Cancer), Stéphane Gingras(Institute for Research in Immunology and Cancer), Jean-François Spinella(Institute for Research in Immunology and Cancer), Sophie Corneau(Institute for Research in Immunology and Cancer), Nadine Mayotte(Institute for Research in Immunology and Cancer), Simon Girard(Institute for Research in Immunology and Cancer), Mélanie Fréchette(Institute for Research in Immunology and Cancer), Valérie Blouin-Chagnon(Institute for Research in Immunology and Cancer), Koryne Leveillé(Institute for Research in Immunology and Cancer), Isabel Boivin(Institute for Research in Immunology and Cancer), Tara MacRae(Institute for Research in Immunology and Cancer), Jana Krošl(Institute for Research in Immunology and Cancer), Clarisse Thiollier(Institute for Research in Immunology and Cancer), Vincent‐Philippe Lavallée(Institute for Research in Immunology and Cancer), Evgeny Kanshin(Institute for Research in Immunology and Cancer), Thierry Bertomeu(Institute for Research in Immunology and Cancer), Jasmin Coulombe‐Huntington(Institute for Research in Immunology and Cancer), Corinne St‐Denis(Institute for Research in Immunology and Cancer), Marie-Ève Bordeleau(Institute for Research in Immunology and Cancer), Geneviève Boucher(Institute for Research in Immunology and Cancer), Philippe P. Roux(Institute for Research in Immunology and Cancer), Sébastien Lemieux(Institute for Research in Immunology and Cancer), Mike Tyers(Institute for Research in Immunology and Cancer), Pierre Thibault(Institute for Research in Immunology and Cancer), Josée Hébert(Hôpital Maisonneuve-Rosemont), Anne Marinier(Institute for Research in Immunology and Cancer), Guy Sauvageau(Hôpital Maisonneuve-Rosemont)

Cancer Cell

July 1, 2019

10.1016/j.ccell.2019.06.003

Cited by 261Open Access

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