RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance

Daniël A. Lionarons(The Francis Crick Institute), David C. Hancock(The Francis Crick Institute), Sareena Rana(Institute of Cancer Research), Philip East(The Francis Crick Institute), Christopher Moore(The Francis Crick Institute), Miguel Murillo(Institute of Cancer Research), Joana Carvalho(The Francis Crick Institute), Bradley Spencer‐Dene(The Francis Crick Institute), Eleanor Herbert(Royal Veterinary College), Gordon Stamp(The Francis Crick Institute), Djamil Damry(The Francis Crick Institute), Dinis Pedro Calado(The Francis Crick Institute), Ian Rosewell(The Francis Crick Institute), Ralph Fritsch(The Francis Crick Institute), Richard R. Neubig(Michigan State University), Míriam Molina‐Arcas(The Francis Crick Institute), Julian Downward(Institute of Cancer Research)
Cancer Cell
June 27, 2019
10.1016/j.ccell.2019.05.015
Cited by 135Open Access
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Abstract

as a promoter of melanoma initiation and mediator of therapy resistance, while identifying SRF/MRTF as a potential therapeutic target.

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