A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9

Yavuz S. Dagdas(University of California, Berkeley), Ahmet Yıldız(University of California, Berkeley), Janice S. Chen(Mammoth Biosciences (United States)), Jennifer A. Doudna(University of California, Berkeley), Samuel H. Sternberg(University of California, Berkeley)
Science Advances
August 4, 2017
10.1126/sciadv.aao0027
Cited by 305

Related Papers

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
|Science|2012|17.2k
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
|Science|2018|4.4k
CRISPR–Cas12-based detection of SARS-CoV-2
|Nature Biotechnology|2020|2.8k
RNA-programmed genome editing in human cells
|eLife|2013|2.1k
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
|Nature|2014|1.9k