Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo
Zhiwei Liao(Huazhong University of Science and Technology), Rongjin Luo(Union Hospital), Gaocai Li(Union Hospital), Yu Song(Huazhong University of Science and Technology), Shengfeng Zhan(Union Hospital), Kangcheng Zhao(Huazhong University of Science and Technology), Wenbin Hua(Union Hospital), Yukun Zhang(Union Hospital), Xinghuo Wu(Union Hospital), Yang Cao(Union Hospital)
Cited by 420Open Access
Abstract
: These results highlight the therapeutic effects of exosomes in preventing IDD progression. Our work is the first to demonstrate that MSC-exos could modulate ER stress-induced apoptosis during AGEs-associated IVD degeneration.
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