Circular RNAs negatively regulate cancer stem cells by physically binding FMRP against CCAR1 complex in hepatocellular carcinoma

Yanjing Zhu(Eastern Hepatobiliary Surgery Hospital), Bo Zheng(Eastern Hepatobiliary Surgery Hospital), Guijuan Luo(Eastern Hepatobiliary Surgery Hospital), Xu-Kai Ma(Chinese Academy of Sciences), Xinyuan Lu(Second Military Medical University), Ximeng Lin(Second Military Medical University), Shuai Yang(Fudan University Shanghai Cancer Center), Qing Zhao(Central South University), Tong Wu(Eastern Hepatobiliary Surgery Hospital), Zhixuan Li(Eastern Hepatobiliary Surgery Hospital), Xiaolong Liu(Mengchao Hepatobiliary Hospital), Rui Wu(Second Military Medical University), Jingfeng Liu(Fujian Medical University), Yang Ge(Shanghai Jiao Tong University), Li Yang(Shanghai Institutes for Biological Sciences), Hongyang Wang(Second Military Medical University), Lei Chen(Second Military Medical University)
Theranostics
January 1, 2019
10.7150/thno.32796
Cited by 322Open Access
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Abstract

Circular RNA (circRNA) possesses great pre-clinical diagnostic and therapeutic potentials in multiple cancers. It has been reported playing roles in multiple malignant behaviors including proliferation, migration, metastasis and chemoresistance. However, the underlying correlation between circRNAs and cancer stem cells (CSCs) has not been reported yet. Methods: circZKSCAN1 level was detected in HCC tissue microarrays to clarify its prognostic values. Gain and loss function experiments were applied to investigate the role of circZKSCAN1 in HCC stemness. Bioinformatic analysis was used to predict the possible downstream RNA binding protein and further RNA immunoprecipitation sequencing was carried out to identify the RBP-regulated genes.

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