Trimethylamine <i>N</i> -oxide–derived zwitterionic polymers: A new class of ultralow fouling bioinspired materials
Bowen Li(University of Washington), Priyesh Jain(University of Washington), Jinrong Ma(University of Washington), Josh Smith(University of Washington), Zhefan Yuan(University of Washington), Hsiang‐Chieh Hung(University of Washington), Yuwei He(University of Washington), Xiaojie Lin(University of Washington), Kan Wu(University of Washington), Jim Pfaendtner(University of Washington), Shaoyi Jiang(University of Washington)
Cited by 286Open Access
Abstract
-oxide (TMAO), a zwitterionic osmolyte and the most effective protein stabilizer, we here report TMAO-derived zwitterionic polymers (PTMAO) as a new class of ultralow fouling biomaterials. The nonfouling properties of PTMAO were demonstrated under highly challenging conditions. The mechanism accounting for the extraordinary hydration of PTMAO was elucidated by molecular dynamics simulations. The discovery of PTMAO polymers demonstrates the power of molecular understanding in the design of new biomimetic materials and provides the biomaterials community with another class of nonfouling zwitterionic materials.
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