Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Annie N. Cowell(University of California San Diego), Eva S. Istvan(Washington University in St. Louis), Amanda K. Lukens(Broad Institute), Marı́a G. Gómez-Lorenzo(GlaxoSmithKline (France)), Manu Vanaerschot(Columbia University), Tomoyo Sakata‐Kato(Harvard University), Erika L. Flannery(University of California San Diego), Pamela Magistrado(Harvard University), Edward Owen(Pennsylvania State University), Matthew Abraham(University of California San Diego), Gregory LaMonte(University of California San Diego), Heather J. Painter(Pennsylvania State University), Roy M. Williams(University of California San Diego), Virginia Franco(GlaxoSmithKline (France)), María Linares(GlaxoSmithKline (France)), Ignacio Arriaga(GlaxoSmithKline (France)), Selina Bopp(Harvard University), Victoria Corey(University of California San Diego), Nina F. Gnädig(Columbia University), Olivia Coburn‐Flynn(Columbia University), Christin Reimer(University of California San Diego), Purva Gupta(University of California San Diego), James M. Murithi(Columbia University), Pedro A. Moura(Columbia University), Olivia Fuchs(University of California San Diego), Erika Sasaki(University of California San Diego), Sang Woon Kim(University of California San Diego), Christine Teng(University of California San Diego), Lawrence Wang(University of California San Diego), Aslı Akidil(Wellcome Sanger Institute), Sophie Adjalley(Wellcome Sanger Institute), Paul Willis(Medicines for Malaria Venture), Dionicio Siegel(University of Montana), Olga Tanaseichuk(Genomics Institute of the Novartis Research Foundation), Zhong Yang(Genomics Institute of the Novartis Research Foundation), Yingyao Zhou(Genomics Institute of the Novartis Research Foundation), Manuel Llinás(Pennsylvania State University), Sabine Ottilie(University of California San Diego), Francisco‐Javier Gamo(GlaxoSmithKline (France)), Lee M(Wellcome Sanger Institute), Daniel E. Goldberg(Washington University in St. Louis), David A. Fidock(Columbia University), Dyann F. Wirth(Broad Institute), Elizabeth A. Winzeler(University of California San Diego)
Cited by 273Open Access
Abstract
Dissecting Plasmodium drug resistance Malaria is a deadly disease with no effective vaccine. Physicians thus depend on antimalarial drugs to save lives, but such compounds are often rendered ineffective when parasites evolve resistance. Cowell et al. systematically studied patterns of Plasmodium falciparum genome evolution by analyzing the sequences of clones that were resistant to diverse antimalarial compounds across the P. falciparum life cycle (see the Perspective by Carlton). The findings identify hitherto unrecognized drug targets and drug-resistance genes, as well as additional alleles in known drug-resistance genes. Science , this issue p. 191 ; see also p. 159
Related Papers
No related papers found
Powered by citation graph analysis