Bacteriophage Resistance Alters Antibiotic-Mediated Intestinal Expansion of Enterococci
Anushila Chatterjee(University of Colorado Denver), Cydney N. Johnson(University of Colorado Denver), Phat Luong(University of Colorado Denver), Karthik Hullahalli(The University of Texas at Dallas), Sara W. McBride(University of Colorado Denver), Alyxandria M. Schubert(Center for Biologics Evaluation and Research), Kelli L. Palmer(The University of Texas at Dallas), Paul E. Carlson(Center for Biologics Evaluation and Research), Breck A. Duerkop(University of Colorado Denver)
Cited by 124Open Access
Abstract
mutant strain is deficient in intestinal colonization, cannot expand its population upon antibiotic-driven intestinal dysbiosis, and fails to be efficiently transmitted to juvenile mice following birth. This study demonstrates that phage therapy could be used in combination with antibiotics to target enterococci within a dysbiotic microbiota. Enterococci that evade phage therapy by developing resistance may be less fit at colonizing the intestine and sensitized to vancomycin, preventing their overgrowth during antibiotic treatment.
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