Efficient Syntheses of Novel C2‘-Alkylated (±)-K252a Analogues
Kazuhiko Tamaki(Yale University), J. Brad Shotwell(Yale University), Ryan D. White(Yale University), Ioana Drutu(Ludwig Cancer Research), Dejah T. Petsch(Yale University), Thao Nheu(Yale University), Hong He(Yale University), Yumiko Hirokawa(Yale University), Hiroshi Maruta(Yale University), John L. Wood(Ludwig Cancer Research)
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Abstract
Recent efforts in our laboratories have resulted in a synthetic approach toward C2'-alkylated K252a analogues via extension of a K252a cyclofuranosylation strategy. The bis-indole-N-glycosidic coupling of 6-N-(3,4-dimethoxybenzyl)-staurosporinone (21) with a number of highly functionalized carbohydrates has given access to previously unattainable, biologically relevant analogues.
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