Spatiotemporal structure of cell fate decisions in murine neural crest
Ruslan Soldatov(Harvard University), Markéta Kaucká(Karolinska Institutet), Maria Eleni Kastriti(Karolinska Institutet), Julian Petersen(Karolinska Institutet), Tatiana Chontorotzea(Karolinska Institutet), Lukas Englmaier(Medical University of Vienna), Natalia Akkuratova(St Petersburg University), Yunshi Yang(Karolinska Institutet), Martin Häring(Karolinska Institutet), Vyacheslav Dyachuk(Karolinska Institutet), Christoph Bock(Austrian Academy of Sciences), Matthias Farlik(Austrian Academy of Sciences), Michael L. Piacentino(California Institute of Technology), Franck Boismoreau(Centre National de la Recherche Scientifique), Markus M. Hilscher(Stockholm University), Chika Yokota(Stockholm University), Xiaoyan Qian(Stockholm University), Mats Nilsson(Stockholm University), Marianne Bronner‐Fraser(California Institute of Technology), Laura Croci(Vita-Salute San Raffaele University), Wen-Yu Hsiao(University of Massachusetts Chan Medical School), David A. Guertin(University of Massachusetts Chan Medical School), Jean‐François Brunet(Centre National de la Recherche Scientifique), G. Giacomo Consalez(Vita-Salute San Raffaele University), Patrik Ernfors(Karolinska Institutet), Kaj Fried(Karolinska Institutet), Peter V. Kharchenko(Harvard University), Igor Adameyko(Karolinska Institutet)
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Abstract
Binary decisions refine fate decisions Neural crest cells develop into tissues ranging from craniofacial bones to peripheral neurons. Combining single-cell RNA sequencing with spatial transcriptomics, Soldatov et al. analyzed how neural crest cells in mouse embryos decide among the various fates available to them (see the Perspective by Mayor). These multipotent cells become biased toward a given fate early on and step through a progression of binary decisions as their fate is refined. Competing fate programs coexist until increased synchronization favors one and repression disfavors the other. Science , this issue p. eaas9536 ; see also p. 937
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