GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores
Niamh Mullins(King's College London), Tim B. Bigdeli(Virginia Commonwealth University), Anders D. Børglum(Aarhus University), Jonathan R. I. Coleman(New York College of Health Professions), Ditte Demontis(Aarhus University), Divya Mehta(The University of Queensland), Robert A. Power(New York College of Health Professions), Stephan Ripke(Massachusetts General Hospital), Eli A. Stahl(Broad Institute), Anna Starnawska(Aarhus University), Adebayo Anjorin(New York College of Health Professions), M.R.C.Psych(New York College of Health Professions), Aiden Corvin(University of Chicago), Alan R. Sanders(Goethe University Frankfurt), Andreas J. Forstner(New York College of Health Professions), Andreas Reif(Goethe University Frankfurt), Anna C. Koller(New York College of Health Professions), Beata Świątkowska(New York College of Health Professions), Bernhard T. Baune(University of Liverpool), Bertram Müller-Myhsok(New York College of Health Professions), Brenda W.J.H. Penninx(SUNY Downstate Health Sciences University), Carlos N. Pato(New York College of Health Professions), Clement C. Zai(New York College of Health Professions), Dan Rujescu(Lundbeck Foundation), David M. Hougaard(New York College of Health Professions), Digby Quested(New York College of Health Professions), Douglas F. Levinson(GGZ inGeest), Elisabeth B. Binder(New York College of Health Professions), Enda M. Byrne(Lundbeck Foundation), Esben Agerbo(New York College of Health Professions), Dr.Med.Sc(New York College of Health Professions), Fabian Streit(New York College of Health Professions), Fermín Mayoral(Goethe University Frankfurt), Frank Bellivier(New York College of Health Professions), Franziska Degenhardt(New York College of Health Professions), Gerome Breen(New York College of Health Professions), Gunnar Morken(New York College of Health Professions), Gustavo Turecki(New York College of Health Professions), Guy A. Rouleau(New York College of Health Professions), Hans J. Grabe(New York College of Health Professions), Henry Völzke(New York College of Health Professions), Ian Jones(New York College of Health Professions), Ina Giegling(New York College of Health Professions), Ingrid Agartz(New York College of Health Professions), Ingrid Melle(New York College of Health Professions), Jacob Lawrence(New York College of Health Professions), M.R.C.Psych(New York College of Health Professions), James Walters(New York College of Health Professions), Jana Strohmaier(New York College of Health Professions), Jianxin Shi(New York College of Health Professions), Joanna Hauser(New York College of Health Professions), Joanna M. Biernacka(New York College of Health Professions), John B. Vincent(New York College of Health Professions), John R. Kelsoe(New York College of Health Professions), John S. Strauss(New York College of Health Professions), Jolanta Lissowska(New York College of Health Professions), Jonathan Pimm(New York College of Health Professions), M.R.C.Psych(New York College of Health Professions), Jordan W. Smoller(New York College of Health Professions), José Guzmán‐Parra(New York College of Health Professions), Klaus Berger(New York College of Health Professions), Laura J. Scott(New York College of Health Professions), Lisa Jones(New York College of Health Professions), Maria Helena Pinto de Azevedo(New York College of Health Professions), Maciej Trzaskowski(New York College of Health Professions), Manolis Kogevinas(New York College of Health Professions), Marcella Rietschel(New York College of Health Professions), Marco P. Boks(New York College of Health Professions), Marcus Ising(New York College of Health Professions), Maria Grigoroiu‐Serbânescu(Goethe University Frankfurt), Marian L. Hamshere(New York College of Health Professions), Marion Leboyer(New York College of Health Professions), Mark A. Frye(New York College of Health Professions), Markus M. Nöthen(New York College of Health Professions), Martin Alda(New York College of Health Professions), Martin Preisig(New York College of Health Professions), Merete Nordentoft(New York College of Health Professions), Michael Boehnke(New York College of Health Professions), Michael O‘Donovan(New York College of Health Professions), Michael J. Owen(New York College of Health Professions), Michele T. Pato(New York College of Health Professions), Miguel E. Rentería(New York College of Health Professions), Monika Budde(New York College of Health Professions), Dipl.-Psych(New York College of Health Professions), Myrna M. Weissman(New York College of Health Professions), Naomi R. Wray(New York College of Health Professions), Nicholas Bass(University of Chicago), M.R.C.Psych(Massachusetts General Hospital), Nicholas Craddock(New York College of Health Professions), Olav B. Smeland(New York College of Health Professions), Ole A. Andreassen(New York College of Health Professions), Ole Mors(New York College of Health Professions), Pablo V. Gejman(New York College of Health Professions), Pamela Sklar(New York College of Health Professions), Patrick J. McGrath(New York College of Health Professions), Per Hoffmann(New York College of Health Professions), Peter McGuffin(New York College of Health Professions), Phil H. Lee(New York College of Health Professions), Preben Bo Mortensen(New York College of Health Professions), René S. Kahn(New York College of Health Professions), Roel A. Ophoff(New York College of Health Professions), Rolf Adolfsson(New York College of Health Professions), Sandra Van der Auwera(New York College of Health Professions), Srdjan Djurovic(New York College of Health Professions), Stefan Kloiber(New York College of Health Professions), Stefanie Heilmann‐Heimbach(New York College of Health Professions), Stéphane Jamain(New York College of Health Professions), Steven P. Hamilton(New York College of Health Professions), Susan L. McElroy(New York College of Health Professions), Susanne Lucae(New York College of Health Professions), Sven Cichon(New York College of Health Professions), Thomas G. Schulze(New York College of Health Professions), Thomas Folkmann Hansen(New York College of Health Professions), Thomas Werge(Virginia Commonwealth University), Tracy Air(New York College of Health Professions), Vishwajit L. Nimgaonkar(New York College of Health Professions), Vivek Appadurai(New York College of Health Professions), Wiepke Cahn(New York College of Health Professions), Yuri Milaneschi(New York College of Health Professions), Ayman H. Fanous(New York College of Health Professions), Kenneth S. Kendler(New York College of Health Professions), Andrew McQuillin(New York College of Health Professions), Cathryn M. Lewis(New York College of Health Professions)
Cited by 282Open Access
Abstract
OBJECTIVE: More than 90% of people who attempt suicide have a psychiatric diagnosis; however, twin and family studies suggest that the genetic etiology of suicide attempt is partially distinct from that of the psychiatric disorders themselves. The authors present the largest genome-wide association study (GWAS) on suicide attempt, using cohorts of individuals with major depressive disorder, bipolar disorder, and schizophrenia from the Psychiatric Genomics Consortium. METHODS: The samples comprised 1,622 suicide attempters and 8,786 nonattempters with major depressive disorder; 3,264 attempters and 5,500 nonattempters with bipolar disorder; and 1,683 attempters and 2,946 nonattempters with schizophrenia. A GWAS on suicide attempt was performed by comparing attempters to nonattempters with each disorder, followed by a meta-analysis across disorders. Polygenic risk scoring was used to investigate the genetic relationship between suicide attempt and the psychiatric disorders. RESULTS: =0.40%). CONCLUSIONS: This study provides new information on genetic associations and demonstrates that genetic liability for major depression increases risk for suicide attempt across psychiatric disorders. Further collaborative efforts to increase sample size may help to robustly identify genetic associations and provide biological insights into the etiology of suicide attempt.
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