CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids

Reyes Gonzalez-Exposito(Institute of Cancer Research), Marco Gerlinger(St Bartholomew's Hospital)
Journal for ImmunoTherapy of Cancer
April 14, 2019
10.1186/s40425-019-0575-3
Cited by 114

Related Papers

Classifying the evolutionary and ecological features of neoplasms
|Nature reviews. Cancer|2017|455
Intratumour Heterogeneity in Urologic Cancers: From Molecular Evidence to Clinical Implications
|European Urology|2014|117
Identifying key questions in the ecology and evolution of cancer
|Evolutionary Applications|2020|98
Circulating Tumour DNA Sequencing Identifies a Genetic Resistance-Gap in Colorectal Cancers with Acquired Resistance to EGFR-Antibodies and Chemotherapy
|Cancers|2020|7
Genetic and immune landscape evolution defines subtypes of MMR deficient colorectal cancer
|bioRxiv (Cold Spring Harbor Laboratory)|2022|1