Identification of a small-molecule compound that inhibits homodimerization of oncogenic NAC1 protein and sensitizes cancer cells to anticancer agents

Xiaohui Wang(Soochow University), Cheng Ji(Soochow University), HongHan Zhang(Soochow University), Shan Yu(Institute of Botany), YiJie Ren(Soochow University), YanWei Hu(Soochow University), LiangRong Shi(Central South University), LingChuan Guo(Soochow University), WeiDong Zhu(Soochow University), YuJuan Xia(Soochow University), BeiJia Liu(Soochow University), ZiYun Rong(Soochow University), BiLian Wu(Soochow University), ZhiJun Ming(Soochow University), Xingcong Ren(University of Kentucky), Jianxun Song(Texas A&M Health Science Center), Jinming Yang(University of Kentucky), Yi Zhang(Soochow University)
Journal of Biological Chemistry
May 17, 2019
10.1074/jbc.ra119.007664
Cited by 24Open Access
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Abstract

These results suggest that small-molecule inhibitors of NAC1 homodimerization may effectively sensitize cancer cells to some anticancer agents and that NAC1 homodimerization could be further explored as a potential therapeutic target in the development of antineoplastic agents.

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