Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6)

Koen P. Rovers; Aeilko H. Zwinderman; Lukas B. Been; Rudolf S.N. Fehrmann; Ninos Ayez; Koert F.D. Kuhlmann; Karin H. Herbschleb; Eva V. E. Madsen; Cornelis B. Hunting; Jacobus W. A. Burger; Marinus J. Wiezer; Geert-Jan Creemers; Djamila Boerma; Nadine L. de Boer; Alexandra R. M. Brandt‐Kerkhof; Checca Bakkers; Schelto Kruijff; Andreas J. A. Bremers; Wilhelmina M. U. van Grevenstein; Hanneke W.M. van Laarhoven; Emma C. E. Wassenaar; Arjen J. Witkamp; Robert J. van Ginkel; Eino B. van Duyn; Jurriaan B. Tuynman; Henk Boot; Derk Jan A. de Groot; Miranda Kusters; Joost Nederend; Leonie J. Mekenkamp; Myriam Chalabi; Geert A. Simkens; Nina R. Sluiter; Miriam Koopman; Simon W. Nienhuijs; Johannes H.W. de Wilt; Max J. Lahaye; Nadia Haj Mohammad; Pétur Snæbjörnsson; Arend G. J. Aalbers; Henk M.W. Verheul; Philip R. de Reuver; Maartje Los; Esther van Meerten; Anna M.J. Thijs; Sandra A. Radema; W. J. B. Mastboom; Niels F.M. Kok; Cornelis Verhoef

doi:10.1186/s12885-019-5545-0

Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6)

Koen P. Rovers(Radboud University Nijmegen), Aeilko H. Zwinderman(Amsterdam Neuroscience), Lukas B. Been(University Medical Center Groningen), Rudolf S.N. Fehrmann(University Medical Center Groningen), Ninos Ayez, Koert F.D. Kuhlmann(The Netherlands Cancer Institute), Karin H. Herbschleb(Radboud University Nijmegen), Eva V. E. Madsen(Erasmus MC), Cornelis B. Hunting(St. Antonius Ziekenhuis), Jacobus W. A. Burger(Radboud University Nijmegen), Marinus J. Wiezer(St. Antonius Ziekenhuis), Geert-Jan Creemers, Djamila Boerma(St. Antonius Ziekenhuis), Nadine L. de Boer(Erasmus University Rotterdam), Alexandra R. M. Brandt‐Kerkhof(Erasmus University Rotterdam), Checca Bakkers(Radboud University Nijmegen), Schelto Kruijff(University Medical Center Groningen), Andreas J. A. Bremers(Radboud University Nijmegen), Wilhelmina M. U. van Grevenstein(University Medical Center Utrecht), Hanneke W.M. van Laarhoven(Dutch Cancer Society), Emma C. E. Wassenaar(St. Antonius Ziekenhuis), Arjen J. Witkamp(University Medical Center Utrecht), Robert J. van Ginkel(University Medical Center Groningen), Eino B. van Duyn(Medisch Spectrum Twente), Jurriaan B. Tuynman(Amsterdam Neuroscience), Henk Boot(The Netherlands Cancer Institute), Derk Jan A. de Groot(University Medical Center Groningen), Miranda Kusters(Radboud University Nijmegen), Joost Nederend(Radboud University Nijmegen), Leonie J. Mekenkamp(Radboud University Nijmegen), Myriam Chalabi(Oncode Institute), Geert A. Simkens(Radboud University Nijmegen), Nina R. Sluiter(Amsterdam University Medical Centers), Miriam Koopman(Utrecht University), Simon W. Nienhuijs(Radboud University Nijmegen), Johannes H.W. de Wilt(Radboud University Nijmegen), Max J. Lahaye(The Netherlands Cancer Institute), Nadia Haj Mohammad(Utrecht University), Pétur Snæbjörnsson(University of Iceland), Arend G. J. Aalbers(The Netherlands Cancer Institute), Henk M.W. Verheul(Erasmus MC Cancer Institute), Philip R. de Reuver(Radboud University Nijmegen), Maartje Los(St. Antonius Ziekenhuis), Esther van Meerten(Erasmus MC Cancer Institute), Anna M.J. Thijs(Radboud University Nijmegen), Sandra A. Radema(Radboud University Nijmegen), W. J. B. Mastboom(Medisch Spectrum Twente), Niels F.M. Kok(The Netherlands Cancer Institute), Cornelis Verhoef(Erasmus MC Cancer Institute)

BMC Cancer

April 25, 2019

10.1186/s12885-019-5545-0

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Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6)

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