Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Leanne K. Küpers(University Medical Center Groningen), Claire Monnereau(Erasmus MC), Gemma C. Sharp(University Of Bristol Dental Hospital), Paul Yousefi(University of Bristol), Lucas A. Salas(Dartmouth College), Akram Ghantous(Centre international de recherche sur le cancer), Christian M. Page(Oslo University Hospital), Sarah E. Reese(National Institutes of Health), Allen J. Wilcox(National Institutes of Health), Darina Czamara(Max Planck Institute of Psychiatry), Anne P. Starling(Colorado School of Public Health), Alexei Novoloaca(Centre international de recherche sur le cancer), Samantha Lent(Boston University), Ritu Roy(University of California, San Francisco), Cathrine Hoyo(North Carolina State University), Carrie V. Breton(University of Southern California), Catherine Allard(Centre Hospitalier Universitaire de Sherbrooke), Allan C. Just(Icahn School of Medicine at Mount Sinai), Kelly M. Bakulski(University of Michigan), John W. Holloway(Southampton General Hospital), Todd M. Everson(Emory University), Cheng‐Jian Xu(University Medical Center Groningen), Rae‐Chi Huang(The Kids Research Institute Australia), Diana A. van der Plaat(University Medical Center Groningen), Matthias Wielscher(Imperial College London), Simon Kebede Merid(Karolinska Institutet), Vilhelmina Ullemar(Karolinska Institutet), Faisal I. Rezwan(Southampton General Hospital), Jari Lahti(University of Helsinki), Jenny van Dongen(Vrije Universiteit Amsterdam), Sabine A. S. Langie(Flemish Institute for Technological Research), Tom G. Richardson(University of Bristol), Maria C. Magnus(Norwegian Institute of Public Health), Ellen A. Nøhr(University of Southern Denmark), Zongli Xu(Erasmus MC), Liesbeth Duijts(Erasmus MC), Shanshan Zhao(National Institute of Environmental Health Sciences), Weimin Zhang(Colorado School of Public Health), Michelle Plusquin(Imperial College London), Dawn L. DeMeo(Brigham and Women's Hospital), Olivia Solomon(University Of Bristol Dental Hospital), Joosje H. Heimovaara(University Medical Center Groningen), Dereje D. Jima(North Carolina State University), Lu Gao(University of Southern California), Mariona Bustamante(Universitat Pompeu Fabra), Patrice Perron(Université de Sherbrooke), Robert O. Wright(Icahn School of Medicine at Mount Sinai), Irva Hertz‐Picciotto(University of California, Davis), Hongmei Zhang(University of Memphis), Margaret R. Karagas(Dartmouth College), Ulrike Gehring(Utrecht University), Carmen J. Marsit(Emory University), Lawrence J. Beilin(The University of Western Australia), Judith M. Vonk(University Medical Center Groningen), Marjo‐Riitta Järvelin(Oulu University Hospital), Anna Bergström(Stockholm County Council), Anne K. Örtqvist(Karolinska Institutet), Susan Ewart(Michigan State University), Pia Villa(University of Helsinki), Sophie E. Moore(King's College London), Gonneke Willemsen(Vrije Universiteit Amsterdam), Arnout Standaert(Flemish Institute for Technological Research), Siri E. Håberg(Norwegian Institute of Public Health), Thorkild I. A. Sørensen(University of Copenhagen), Jack A. Taylor(National Institutes of Health), Katri Räikkönen(University of Helsinki), Ivana V. Yang(University of Colorado Anschutz Medical Campus), Katerina Kechris(Erasmus MC), Tim S. Nawrot(Hasselt University), Matt J. Silver(London School of Hygiene & Tropical Medicine), Yun Yun Gong(University of Leeds), Lorenzo Richiardi(Azienda Ospedaliera Citta' della Salute e della Scienza di Torino), Manolis Kogevinas(Universitat Pompeu Fabra), Augusto A. Litonjua(Brigham and Women's Hospital), Brenda Eskenazi(Center for Environmental Health), Karen Huen(University of California, Berkeley), Hamdi Mbarek(Vrije Universiteit Amsterdam), Rachel L. Maguire(North Carolina State University), Terence Dwyer(The George Institute for Global Health), Martine Vrijheid(Universitat Pompeu Fabra), Luigi Bouchard(Université de Sherbrooke), Andrea Baccarelli(Columbia University), Lisa Croen(Kaiser Permanente), Wilfried Karmaus(University of Memphis), Denise Anderson(The Kids Research Institute Australia), Maaike de Vries(University Medical Center Groningen), Sylvain Sebért(Public Health England), Juha Kere(Guy's Hospital), Robert Karlsson(Karolinska Institutet), Syed Hasan Arshad(David Hide Asthma and Allergy Research Centre), Esa Hämäläinen(University of Helsinki), Michael N. Routledge(University of Leeds), Dorret I. Boomsma(Vrije Universiteit Amsterdam), Andrew P. Feinberg(Johns Hopkins University), Craig J. Newschaffer(Drexel University), Eva Govarts(Flemish Institute for Technological Research), Matthieu Moisse(VIB-KU Leuven Center for Brain & Disease Research), M. Daniele Fallin(Johns Hopkins University), Erik Melén(Karolinska Institutet), Andrew M. Prentice(London School of Hygiene & Tropical Medicine), Eero Kajantie(University of Helsinki), Catarina Almqvist(Karolinska University Hospital), Emily Oken(Harvard University), Dana Dabelea(Colorado School of Public Health), H. Marike Boezen(University Medical Center Groningen), Phillip E. Melton(The University of Western Australia), Rosalind J. Wright(Icahn School of Medicine at Mount Sinai), Gerard H. Koppelman(University Medical Center Groningen), Letizia Trevisi(Harvard University), Marie‐France Hivert(Université de Sherbrooke), Jordi Sunyer(Universitat Pompeu Fabra), Monica Cheng Munthe‐Kaas(Oslo University Hospital), Susan K. Murphy(Duke Medical Center), Eva Corpeleijn(University Medical Center Groningen), Joseph L. Wiemels(University of California, San Francisco), Nina Holland(University of California, Berkeley), Zdenko Herceg(Centre international de recherche sur le cancer), Elisabeth B. Binder(Emory University), George Davey Smith(University of Bristol), Vincent W. V. Jaddoe(Erasmus MC), Rolv T. Lie(Norwegian Institute of Public Health), Wenche Nystad(Norwegian Institute of Public Health), Stephanie J. London(National Institutes of Health), Debbie A. Lawlor(At Bristol), Caroline L. Relton(At Bristol), Harold Snieder(University Medical Center Groningen), Janine F. Felix(Erasmus MC)
Cited by 263Open Access
Abstract
Abstract Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from −183 to 178 grams per 10% increase in methylation (P Bonferroni < 1.06 x 10 −7 ). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10 −74 ) and BMI in pregnancy (3/914, p = 1.13x10 −3 ), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth influencing DNA methylation (i.e. reverse causality) requires further research.
Related Papers
No related papers found
Powered by citation graph analysis