METTL3 and ALKBH5 oppositely regulate m<sup>6</sup>A modification of <i>TFEB</i> mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes
Huiwen Song(Zunyi Medical University), Xing Feng(Rutgers, The State University of New Jersey), Heng Zhang(Central South University), Yun Luo(Zunyi Medical University), Juan Huang(Zunyi Medical University), Meihua Lin(First Affiliated Hospital Zhejiang University), Junfei Jin(Guilin Medical University), Xue Ding(Harbin Medical University), Shu-Jing Wu(Xiamen University), He Huang(Central South University), Tian Yu(Zunyi Medical University), Mukun Zhang(Anhui Provincial Hospital), Haiou Hong(Anhui Provincial Hospital), Shihua Yao(Second Military Medical University), Yongxiang Zhao(Guangxi Medical University), Zhiyong Zhang(Rutgers, The State University of New Jersey)
Cited by 539Open Access
Abstract
-methyladenosine; MEFs, mouse embryo fibroblasts; Mer, mutated estrogen receptor domains; METTL3, methyltransferase like 3; METTL14, methyltransferase like 14; mRFP, monomeric red fluorescent protein; MTORC1, mechanistic target of rapamycin kinase complex 1; NMVCs, neonatal mouse ventricular cardiomyocytes; PCNA, proliferating cell nuclear antigen; PE, phosphatidylethanolamine; PI, propidium iodide; PTMs, post-translational modifications; PVDF, polyvinylidenedifluoride; RIP, RNA-immunoprecipitation; siRNA, small interfering RNA; SQSTM1, sequestosome 1; TFEB, transcription factor EB; TUBA: tublin alpha; WTAP, WT1 associated protein; YTHDF, YTH N6-methyladenosine RNA binding protein.
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