Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

Svetoslav Chakarov(Singapore Immunology Network), Hwee Ying Lim(National University of Singapore), Leonard Tan(Singapore Immunology Network), Sheau Yng Lim(National University of Singapore), Peter See(Singapore Immunology Network), Josephine Lum(Singapore Immunology Network), Xiaomeng Zhang(Singapore Immunology Network), Shihui Foo(Singapore Immunology Network), Satoshi Nakamizo(Singapore Immunology Network), Kaibo Duan(Singapore Immunology Network), Wan Ting Kong(Singapore Immunology Network), Rebecca Gentek(Centre National de la Recherche Scientifique), Akhila Balachander(Singapore Immunology Network), Daniel Carbajo(Singapore Immunology Network), Camille Blériot(Singapore Immunology Network), Benoît Malleret(National University of Singapore), John Kit Chung Tam(National University of Singapore), Sonia Baig(National University of Singapore), Muhammad Shabeer(National University of Singapore), Sue‐Anne Toh(National University of Singapore), Andreas Schlitzer(University of Bonn), Anis Larbi(Singapore Immunology Network), Thomas Marichal(University of Liège), Bernard MALISSEN(Centre National de la Recherche Scientifique), Jinmiao Chen(Singapore Immunology Network), Michael Poidinger(Singapore Immunology Network), Kenji Kabashima(Kyoto University), Marc Bajénoff(Centre National de la Recherche Scientifique), Lai Guan Ng(Singapore Immunology Network), Véronique Angeli(National University of Singapore), Florent Ginhoux(Singapore Immunology Network)
Science
March 14, 2019
10.1126/science.aau0964
Cited by 1,089

Abstract

Tissue macrophages have a split personality Resident tissue macrophages (RTMs) reside in various tissue-specific niches during development. They evince microenvironment-directed phenotypes that support host defense and tissue homeostasis. Chakarov et al. used single-cell RNA sequencing and fate-mapping of murine lung RTMs to interrogate RTM-subset heterogeneity, interrelationships, and ontogeny (see the Perspective by Mildner and Yona). In addition to alveolar macrophages, they identified two different interstitial macrophage populations. One population mostly abutted nerve fibers; the other population preferentially localized near blood vessels and appeared to support vessel integrity and inhibit inflammatory cell infiltration into tissues. Science , this issue p. eaau0964 ; see also p. 1154

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