Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
Michelle Daya(University of Colorado Denver), Nicholas Rafaels(University of Colorado Denver), Tonya M. Brunetti(University of Colorado Denver), Sameer Chavan(University of Colorado Denver), Albert M. Levin(Henry Ford Health System), Aniket Shetty(University of Colorado Denver), Christopher R. Gignoux(University of Colorado Denver), Meher Preethi Boorgula(University of Colorado Denver), Genevieve L. Wojcik(Stanford University), Monica Campbell(University of Colorado Denver), Candelaria Vergara(Johns Hopkins University), Dara G. Torgerson(University of California, San Francisco), Victor E. Ortega(Wake Forest University), Ayo P. Doumatey(National Institutes of Health), H. Richard Johnston(Emory University), Nathalie Acevedo(University of Cartagena), Maria Ilma Araújo(Universidade Federal da Bahia), Pedro C. Avila(Northwestern University), Gillian M. Belbin(Icahn School of Medicine at Mount Sinai), Eugene R. Bleecker(University of Arizona), Carlos D. Bustamante(Stanford University), Luis Caraballo(University of Cartagena), Ãlvaro A. Cruz(Universidade Federal da Bahia), Georgia M. Dunston(Howard University), Celeste Eng(University of California, San Francisco), Mezbah U. Faruque(Howard University), Trevor S. Ferguson(University of the West Indies), Camila Alexandrina Figueiredo(Universidade Federal da Bahia), Jean G. Ford(Einstein Medical Center Philadelphia), Weiniu Gan(National Institutes of Health), Pierre‐Antoine Gourraud(Inserm), Nadia N. Hansel(Johns Hopkins University), Ryan D. Hernandez(University of California, San Francisco), Edwin Francisco Herrera-Paz(Central American Technological University), Silvia Jiménez(University of Cartagena), Eimear E. Kenny(Icahn School of Medicine at Mount Sinai), Jennifer Knight‐Madden(University of the West Indies), Rajesh Kumar(Northwestern University), Leslie A. Lange(University of Colorado Denver), Ethan M. Lange(University of Colorado Denver), Antoine Lizée(Inserm), Pissamai Maul(University of the West Indies), Trevor Maul(University of the West Indies), Alvaro Mayorga(Honduras Foundation for Agricultural Research), Deborah A. Meyers(University of Arizona), Dan L. Nicolae(University of Chicago), Timothy D. O’Connor(University of Maryland, Baltimore), Ricardo Riccio Oliveira, Christopher O. Olopade(University of Chicago), Olufunmilayo I. Olopade(University of Chicago), Zhaohui Qin(Emory University), Charles N. Rotimi(National Institutes of Health), Nicolas Vince(Inserm), Harold Watson(University of the West Indies), Rainford Wilks(University of the West Indies), James G. Wilson(Jackson Memorial Hospital), Steven L. Salzberg(Johns Hopkins University), Carole Ober(University of Chicago), Esteban G. Burchard(University of California, San Francisco), L. Keoki Williams(Henry Ford Health System), Terri H. Beaty(Johns Hopkins University), Margaret A. Taub(Johns Hopkins University), Ingo Ruczinski(Johns Hopkins University), Rasika A. Mathias(Johns Hopkins University), Kathleen C. Barnes(University of Colorado Denver), CAAPA(Centre de Recherche Médicales de Lambaréné), Ayôla Akim Adégnika(University of Ibadan), Ganiyu Arinola(University of Ibadan), Ulysse Ateba-Ngoa(Centre de Recherche Médicales de Lambaréné), Gerardo Ayestas(University of Iceland), Hrafnhildur Bjarnadóttir(University of Iceland), Adolfo Correa(Jackson Memorial Hospital), Said Omar Leiva Erazo(Universidad Católica de Honduras Nuestra Señora Reina de la Paz), Marilyn G. Foreman(Johns Hopkins University), Cassandra Foster(Johns Hopkins University), Li Gao(Johns Hopkins University), Jingjing Gao(Northwestern University), Leslie C. Grammer(Northwestern University), Mark Hansen(Illumina (United States)), Tina V. Hartert(Emory University), Yi‐Juan Hu(Emory University), Iain R. Konigsberg(Northwestern University), Kwang‐Youn A. Kim(Northwestern University), Pamela Landaverde-Torres(University of Cartagena), Javier Marrugo(University of Cartagena), B. Martínez(University of Cartagena), Rosella Martinez(Universidad Católica de Honduras Nuestra Señora Reina de la Paz), L Mayorga(Central American Technological University), Delmy-Aracely Mejia-Mejia(University of Cartagena), Catherine Meza(University of Cartagena), Solomon K. Musani(Jackson Memorial Hospital), Shaila Musharoff(University of Chicago), Oluwafemi Oluwole(University of California, San Francisco), Maria Pino‐Yanes(University of California, San Francisco), Hector Ramos(Universidad Católica de Honduras Nuestra Señora Reina de la Paz), Allan Saenz(Universidad Católica de Honduras Nuestra Señora Reina de la Paz), Maureen Samms‐Vaughan(Northwestern University), R.P. Schleimer(Northwestern University), Alan F. Scott(Johns Hopkins University), Suyash Shringarpure(University of Maryland, Baltimore), Wei Song(University of Maryland, Baltimore), Zachary A. Szpiech(University of California, San Francisco), R. A. de A. Torres(University of California, San Francisco), Gloria Varela(Universidad Católica de Honduras Nuestra Señora Reina de la Paz), Olga Marina Vasquez(Honduras Foundation for Agricultural Research), Francisco M. De La Vega(Vanderbilt University), Lorraine B. Ware(Vanderbilt University), Maria Yazdanbakhsh(Leiden University Medical Center)
Cited by 101Open Access
Abstract
Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12-q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.
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