MODOMICS: a database of RNA modification pathways. 2017 update

Pietro Boccaletto(International Institute of Molecular and Cell Biology), Magdalena A. Machnicka(International Institute of Molecular and Cell Biology), Elżbieta Purta(International Institute of Molecular and Cell Biology), Paweł Piątkowski(International Institute of Molecular and Cell Biology), Błażej Bagiński(International Institute of Molecular and Cell Biology), Tomasz Wirecki(International Institute of Molecular and Cell Biology), Valérie de Crécy‐Lagard(University of Florida), Robert Ross(University of Cincinnati), Patrick A. Limbach(University of Cincinnati), Annika Kötter(Johannes Gutenberg University Mainz), Mark Helm(Johannes Gutenberg University Mainz), Janusz M. Bujnicki(International Institute of Molecular and Cell Biology)
Nucleic Acids Research
October 18, 2017
10.1093/nar/gkx1030
Cited by 1,935Open Access
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Abstract

MODOMICS is a database of RNA modifications that provides comprehensive information concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways, the location of modified residues in RNA sequences, and RNA-modifying enzymes. In the current database version, we included the following new features and data: extended mass spectrometry and liquid chromatography data for modified nucleosides; links between human tRNA sequences and MINTbase - a framework for the interactive exploration of mitochondrial and nuclear tRNA fragments; new, machine-friendly system of unified abbreviations for modified nucleoside names; sets of modified tRNA sequences for two bacterial species, updated collection of mammalian tRNA modifications, 19 newly identified modified ribonucleosides and 66 functionally characterized proteins involved in RNA modification. Data from MODOMICS have been linked to the RNAcentral database of RNA sequences. MODOMICS is available at http://modomics.genesilico.pl.

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