Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

Benjamin P. Kleinstiver(Harvard University), Alexander A. Sousa(Massachusetts General Hospital), Russell T. Walton(Massachusetts General Hospital), Y. Esther Tak(Harvard University), Jonathan Y. Hsu(Massachusetts General Hospital), Kendell Clement(Broad Institute), Moira M. Welch(Massachusetts General Hospital), Joy E. Horng(Massachusetts General Hospital), Jose Malagon-Lopez(Harvard University), Irene Scarfò(Harvard University), Marcela V. Maus(Harvard University), Luca Pinello(Broad Institute), Martin J. Aryee(Broad Institute), J. Keith Joung(Harvard University)
Nature Biotechnology
February 11, 2019
Cited by 718

Abstract


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