Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles
Boshi Huang(Virginia Commonwealth University), Xinyong Liu(Shandong University of Traditional Chinese Medicine), Tiziana Ginex(Universitat de Barcelona), Xiangyi Jiang(Shandong University), Erik De Clercq(Rega Institute for Medical Research), Wen‐Ming Chen(Guangzhou University of Chinese Medicine), Ping Gao(University of Science and Technology of China), F. Javier Luque(Universidad Complutense de Madrid), Christophe Pannecouque(Rega Institute for Medical Research), David Vı́lchez(University of Cologne), Dongwei Kang(Shandong University), Dirk Daelemans(Rega Institute for Medical Research), Peng Zhan(Shandong University of Traditional Chinese Medicine), Zhenyu Li, Ye Tian(Jilin University), Tong Zhao(China Pharmaceutical University)
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