Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation
Mutsuko Minata(University of Alabama at Birmingham), Alessandra Audia(The University of Texas MD Anderson Cancer Center), Junfeng Shi(The Ohio State University), Songjian Lu(University of Pittsburgh), Joshua D. Bernstock(University of Alabama at Birmingham), Marat S. Pavlyukov(Institute of Bioorganic Chemistry), Arvid Das(The University of Texas MD Anderson Cancer Center), Sung-Hak Kim(Chonnam National University), Yong Jae Shin(Samsung (South Korea)), Yeri Lee(Samsung Medical Center), Harim Koo(Samsung Medical Center), Kirti Snigdha(University of Dayton), Indrayani Waghmare(University of Dayton), Xing Guo(Shandong University), Ahmed Mohyeldin(University of Alabama at Birmingham), Daniel Gallego‐Perez(The Ohio State University), Jia Wang(University of Alabama at Birmingham), Dongquan Chen(University of Alabama at Birmingham), Peng Cheng(University of Alabama at Birmingham), Farah Mukheef(The University of Texas MD Anderson Cancer Center), Minerva Contreras(The University of Texas MD Anderson Cancer Center), Joel F. Reyes(The University of Texas MD Anderson Cancer Center), Brian Vaillant(The University of Texas at Austin), Erik P. Sulman(The University of Texas MD Anderson Cancer Center), Shi‐Yuan Cheng(Northwestern University), James M. Markert(University of Alabama at Birmingham), Bakhos A. Tannous(Harvard University), Xinghua Lu(University of Pittsburgh), Madhuri Kango‐Singh(University of Dayton), L. James Lee(The Ohio State University), Do‐Hyun Nam(Samsung (South Korea)), Ichiro Nakano(University of Alabama at Birmingham), Krishna Bhat(The University of Texas MD Anderson Cancer Center)
Cited by 216Open Access
Abstract
cells are highly enriched with clonogenic, tumor-initiating, and radiation-resistant properties, and silencing CD109 significantly inhibits these phenotypes. We also report a conserved regulation of YAP/TAZ pathways by CD109 that could be a therapeutic target in GBM.