SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis

Guihua Wang; Jie Long; Yuan Gao; Weina Zhang; Fei Han; Chuan Xu; Li Sun; Shun-Chin Yang; Jingqin Lan; Zhenlin Hou; Zhen Cai; Guoxiang Jin; Che-Chia Hsu; Yu-Hui Wang; Junbo Hu; Tsai‐Yu Chen; Hongyu Li; Min Gyu Lee; Hui‐Kuan Lin

doi:10.1038/s41556-018-0266-1

SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis

Guihua Wang(Atrium Health Wake Forest Baptist), Jie Long(Atrium Health Wake Forest Baptist), Yuan Gao(The University of Texas MD Anderson Cancer Center), Weina Zhang(Atrium Health Wake Forest Baptist), Fei Han(Atrium Health Wake Forest Baptist), Chuan Xu(Atrium Health Wake Forest Baptist), Li Sun(Atrium Health Wake Forest Baptist), Shun-Chin Yang(Atrium Health Wake Forest Baptist), Jingqin Lan(Tongji Hospital), Zhenlin Hou(Tongji Hospital), Zhen Cai(Atrium Health Wake Forest Baptist), Guoxiang Jin(Atrium Health Wake Forest Baptist), Che-Chia Hsu(Atrium Health Wake Forest Baptist), Yu-Hui Wang(Atrium Health Wake Forest Baptist), Junbo Hu(Tongji Hospital), Tsai‐Yu Chen(The University of Texas MD Anderson Cancer Center), Hongyu Li(University of Arkansas for Medical Sciences), Min Gyu Lee(The University of Texas MD Anderson Cancer Center), Hui‐Kuan Lin(Atrium Health Wake Forest Baptist)

Nature Cell Biology

January 28, 2019

10.1038/s41556-018-0266-1

Cited by 198Open Access

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