Characterization and Optimization of Multiplexed Quantitative Analyses Using High-Field Asymmetric-Waveform Ion Mobility Mass Spectrometry
Devin K. Schweppe(Harvard University), Satendra Prasad(Thermo Fisher Scientific (United States)), Michael W. Belford(Thermo Fisher Scientific (United States)), José Navarrete-Perea(Harvard University), Derek J. Bailey(Thermo Fisher Scientific (United States)), Romain Huguet(Thermo Fisher Scientific (United States)), Mark P. Jedrychowski(Harvard University), Ramin Rad(Harvard University), Graeme C. McAlister(Thermo Fisher Scientific (United States)), Susan E. Abbatiello(Thermo Fisher Scientific (United States)), Eloy R. Woulters(Thermo Fisher Scientific (United States)), Vlad Zabrouskov(Thermo Fisher Scientific (United States)), Jean‐Jacques Dunyach(Thermo Fisher Scientific (United States)), João A. Paulo(Harvard University), Steven P. Gygi(Harvard University)
Cited by 244Open Access
Abstract
)-based methods without sacrificing protein identifications. We further optimized and characterized the main factors that enable robust use of FAIMS for multiplexed quantitation. We highlight these factors and provide method recommendations to take advantage of FAIMS technology to improve isobaric-tag-quantification moving forward.
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