The Liver Tumor Segmentation Benchmark (LiTS)

Patrick Bilic(Technical University of Munich), Patrick Ferdinand Christ(Technical University of Munich), Hongwei Li(Guangdong University of Foreign Studies), Eugene Vorontsov(Polytechnique Montréal), Avi Ben-Cohen(Tel Aviv University), Georgios Kaissis(TUM Klinikum), Adi Szeskin(Hebrew University of Jerusalem), Colin Jacobs(Radboud University Nijmegen), Gabriel Efrain Humpire Mamani(Radboud University Nijmegen), Gabriel Chartrand(Université de Montréal), Fabian Lohöfer(TUM Klinikum), Julian Walter Holch(German Cancer Research Center), Wieland H. Sommer(LMU Klinikum), Felix Hofmann(LMU Klinikum), Alexandre Hostettler(Institut de Recherche contre les Cancers de l’Appareil Digestif), Naama Lev‐Cohain(Hadassah Medical Center), Michal Drozdzal(Polytechnique Montréal), Michal Amitai(Sheba Medical Center), Refael Vivanti(Rafael Advanced Defense Systems (Israel)), Jacob Sosna(Hadassah Medical Center), Ivan Ezhov(Rafael Advanced Defense Systems (Israel)), Anjany Sekuboyina(University of Zurich), Fernando Navarro(Board of the Swiss Federal Institutes of Technology), Florian Kofler(TUM Klinikum), Johannes C. Paetzold(Helmholtz Zentrum München), Suprosanna Shit(Chinese University of Hong Kong), Xiaobin Hu(Radboud University Nijmegen), Jana Lipková(Brigham and Women's Hospital), Markus Rempfler(Board of the Swiss Federal Institutes of Technology), Marie Piraud(Helmholtz Zentrum München), Jan S. Kirschke(TUM Klinikum), Benedikt Wiestler(TUM Klinikum), Zhiheng Zhang(Nanjing Drum Tower Hospital), Christian Hülsemeyer(Board of the Swiss Federal Institutes of Technology), Marcel Beetz(Technical University of Munich), Florian Ettlinger(Technical University of Munich), Michela Antonelli(King's College London), Woong Bae(Hong Kong University of Science and Technology), Míriam Bellver(Barcelona Supercomputing Center), Lei Bi(The University of Sydney), Hao Chen(Hong Kong University of Science and Technology), Grzegorz Chlebus(Radboud University Nijmegen), Erik B. Dam(University of Copenhagen), Qi Dou(Chinese University of Hong Kong), Chi‐Wing Fu(Chinese University of Hong Kong), Bogdan Georgescu(Siemens Healthcare (United States)), Xavier Giró-i-Nieto(Heidelberg University), Felix Gruen(LMU Klinikum), Xu Han(University of North Carolina Health Care), Pheng‐Ann Heng(Chinese University of Hong Kong), Jürgen Hesser(Heidelberg University), Jan Hendrik Moltz(Fraunhofer Institute for Digital Medicine), Christian Igel(University of Copenhagen), Fabian Isensee(German Cancer Research Center), Paul F. Jäger(German Cancer Research Center), Fucang Jia(Chinese Academy of Sciences), Krishna Chaitanya Kaluva(Indian Institute of Technology Madras), Mahendra Khened(Indian Institute of Technology Madras), Ildoo Kim(LMU Klinikum), Jae Hun Kim(Samsung Medical Center), Sungwoong Kim(Korea Brain Research Institute), Simon Köhl(German Cancer Research Center), Tomasz Konopczyński(Heidelberg University), Avinash Kori(Indian Institute of Technology Madras), Ganapathy Krishnamurthi(Hong Kong University of Science and Technology), Fan Li(LMU Klinikum), Hongchao Li(Guangdong University of Foreign Studies), Junbo Li(LMU Klinikum), Xiaomeng Li(LMU Klinikum), John Lowengrub(University of California, Irvine), Jun Ma(Sheba Medical Center), Klaus Maier‐Hein(German Cancer Research Center), Kevis-Kokitsi Maninis(Board of the Swiss Federal Institutes of Technology), Hans Meine(University of Bremen), Dorit Merhof(RWTH Aachen University), Akshay Pai(University of Copenhagen), Mathias Perslev(University of Copenhagen), Jens Petersen(German Cancer Research Center), Jordi Pont-Tuset(Board of the Swiss Federal Institutes of Technology), Qi Jin(University of Electronic Science and Technology of China), Xiaojuan Qi(University of Hong Kong), Oliver Rippel(RWTH Aachen University), Karsten Roth(University of Tübingen), Ignacio Sarasúa(TUM Klinikum), Andrea Schenk(Medizinische Hochschule Hannover), Zengming Shen(University of Illinois Urbana-Champaign), Jordi Torres(Universitat Politècnica de Catalunya), Christian Wachinger(TUM Klinikum), Chunliang Wang(KTH Royal Institute of Technology), Leon Weninger(RWTH Aachen University), Jianrong Wu(LMU Klinikum), Daguang Xu(Nvidia (United States)), Xiaoping Yang(Nanjing University), Simon C.H. Yu(Chinese University of Hong Kong), Yading Yuan(Icahn School of Medicine at Mount Sinai), Yue Miao(GGG (France)), Liping Zhang(Chinese University of Hong Kong), M. Jorge Cardoso(King's College London), Spyridon Bakas(Rafael Advanced Defense Systems (Israel)), Rickmer Braren(TUM Klinikum), Volker Heinemann(LMU Klinikum), Christopher Pal(Polytechnique Montréal), An Tang(Université de Montréal), Samuel Kadoury(Polytechnique Montréal), Luc Soler(Institut de Recherche contre les Cancers de l’Appareil Digestif), Bram van Ginneken(Radboud University Nijmegen), Hayit Greenspan(Tel Aviv University), Leo Joskowicz(Hebrew University of Jerusalem), Bjoern Menze(Quantitative BioSciences)
Medical Image Analysis
November 17, 2022
Cited by 1,140Open Access
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Abstract

In this work, we report the set-up and results of the Liver Tumor Segmentation Benchmark (LiTS), which was organized in conjunction with the IEEE International Symposium on Biomedical Imaging (ISBI) 2017 and the International Conferences on Medical Image Computing and Computer-Assisted Intervention (MICCAI) 2017 and 2018. The image dataset is diverse and contains primary and secondary tumors with varied sizes and appearances with various lesion-to-background levels (hyper-/hypo-dense), created in collaboration with seven hospitals and research institutions. Seventy-five submitted liver and liver tumor segmentation algorithms were trained on a set of 131 computed tomography (CT) volumes and were tested on 70 unseen test images acquired from different patients. We found that not a single algorithm performed best for both liver and liver tumors in the three events. The best liver segmentation algorithm achieved a Dice score of 0.963, whereas, for tumor segmentation, the best algorithms achieved Dices scores of 0.674 (ISBI 2017), 0.702 (MICCAI 2017), and 0.739 (MICCAI 2018). Retrospectively, we performed additional analysis on liver tumor detection and revealed that not all top-performing segmentation algorithms worked well for tumor detection. The best liver tumor detection method achieved a lesion-wise recall of 0.458 (ISBI 2017), 0.515 (MICCAI 2017), and 0.554 (MICCAI 2018), indicating the need for further research. LiTS remains an active benchmark and resource for research, e.g., contributing the liver-related segmentation tasks in http://medicaldecathlon.com/. In addition, both data and online evaluation are accessible via https://competitions.codalab.org/competitions/17094.


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