Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Richard Karlsson Linnér; Pietro Biroli; Edward Kong; S. Fleur W. Meddens; Robbee Wedow; Mark Alan Fontana; Maël P. Lebreton; Stephen P. Tino; Abdel Abdellaoui; Anke R. Hammerschlag; Michel G. Nivard; Aysu Okbay; Cornelius A. Rietveld; Pascal Timshel; Maciej Trzaskowski; Ronald de Vlaming; Christian Zünd; Yanchun Bao; Laura Buzdugan; Ann H. Caplin; Chia‐Yen Chen; Peter Eibich; Pierre Fontanillas; Juan R. González; Peter K. Joshi; Ville Karhunen; Aaron Kleinman; Remy Z. Levin; Christina M. Lill; Gerardus A. Meddens; Gerard Muntané; Sandra Sanchez‐Roige; Frank J.A. van Rooij; Erdogan Taskesen; Yang Wu; Futao Zhang; Adam Auton; Jason D. Boardman; David W. Clark; Andrew Conlin; Conor Dolan; Urs Fischbacher; Patrick J. F. Groenen; Kathleen Mullan Harris; Gregor Hasler; Albert Hofman; M. Arfan Ikram; Sonia Jain; Robert Karlsson; Ronald C. Kessler; Maarten Kooyman; James MacKillop; Minna Männikkö; Carlos Morcillo-Suárez; Matthew B. McQueen; Klaus M. Schmidt; Melissa Smart; Matthias Sutter; Roy Thurik; André G. Uitterlinden; Jon White; Harriet de Wit; Jian Yang; Lars Bertram; Dorret I. Boomsma; Tõnu Esko; Ernst Fehr; David A. Hinds; Magnus Johannesson; Meena Kumari; David Laibson; Patrik K. E. Magnusson; Michelle N. Meyer; Arcadi Navarro; Abraham A. Palmer; Tune H. Pers; Daniëlle Posthuma; Daniel Schunk; Murray B. Stein; Rauli Svento; Henning Tiemeier; Paul R. H. J. Timmers; Patrick Turley; Robert J. Ursano; Gert G. Wagner; James F. Wilson; Jacob Gratten; James J. Lee; David Cesarini; Daniel J. Benjamin; Philipp Koellinger; Jonathan Beauchamp

doi:10.1038/s41588-018-0309-3

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Richard Karlsson Linnér(Amsterdam Neuroscience), Pietro Biroli(University of Zurich), Edward Kong(Harvard University), S. Fleur W. Meddens(Amsterdam Neuroscience), Robbee Wedow(Broad Institute), Mark Alan Fontana(Hospital for Special Surgery), Maël P. Lebreton(University of Amsterdam), Stephen P. Tino(University of Toronto), Abdel Abdellaoui(Vrije Universiteit Amsterdam), Anke R. Hammerschlag(Amsterdam Neuroscience), Michel G. Nivard(Vrije Universiteit Amsterdam), Aysu Okbay(Amsterdam Neuroscience), Cornelius A. Rietveld(Erasmus MC), Pascal Timshel(Statens Serum Institut), Maciej Trzaskowski(The University of Queensland), Ronald de Vlaming(Amsterdam Neuroscience), Christian Zünd(University of Zurich), Yanchun Bao(University of Essex), Laura Buzdugan(University of Zurich), Ann H. Caplin, Chia‐Yen Chen(Broad Institute), Peter Eibich(German Institute for Economic Research), Pierre Fontanillas(23andMe (United States)), Juan R. González(Universitat Pompeu Fabra), Peter K. Joshi(Centre for Global Health Research), Ville Karhunen(University of Oulu), Aaron Kleinman(23andMe (United States)), Remy Z. Levin(University of California San Diego), Christina M. Lill(University of Lübeck), Gerardus A. Meddens(Western Digital (Netherlands)), Gerard Muntané(Universitat Pompeu Fabra), Sandra Sanchez‐Roige(University of California San Diego), Frank J.A. van Rooij(Erasmus MC), Erdogan Taskesen(Amsterdam Neuroscience), Yang Wu(The University of Queensland), Futao Zhang(The University of Queensland), Adam Auton(23andMe (United States)), Jason D. Boardman(University of Colorado Boulder), David W. Clark(Centre for Global Health Research), Andrew Conlin(University of Oulu), Conor Dolan(Vrije Universiteit Amsterdam), Urs Fischbacher(University of Konstanz), Patrick J. F. Groenen(Rotterdam University of Applied Sciences), Kathleen Mullan Harris(University of North Carolina at Chapel Hill), Gregor Hasler(University of Fribourg), Albert Hofman(Harvard University), M. Arfan Ikram(Erasmus MC), Sonia Jain(University of California San Diego), Robert Karlsson(Karolinska Institutet), Ronald C. Kessler(Harvard University), Maarten Kooyman(SURFsara (Netherlands)), James MacKillop(Homewood Research Institute), Minna Männikkö(University of Oulu), Carlos Morcillo-Suárez(Universitat Pompeu Fabra), Matthew B. McQueen(University of Colorado Boulder), Klaus M. Schmidt, Melissa Smart(University of Essex), Matthias Sutter(University of Cologne), Roy Thurik(Montpellier Business School), André G. Uitterlinden(Erasmus University Rotterdam), Jon White(University College London), Harriet de Wit(University of Chicago), Jian Yang(The University of Queensland), Lars Bertram(OsloMet – Oslo Metropolitan University), Dorret I. Boomsma(Vrije Universiteit Amsterdam), Tõnu Esko(University of Tartu), Ernst Fehr(University of Zurich), David A. Hinds(23andMe (United States)), Magnus Johannesson(Stockholm School of Economics), Meena Kumari(University of Essex), David Laibson(Harvard University), Patrik K. E. Magnusson(Karolinska Institutet), Michelle N. Meyer(Geisinger Health System), Arcadi Navarro(Institució Catalana de Recerca i Estudis Avançats), Abraham A. Palmer(University of California San Diego), Tune H. Pers(Statens Serum Institut), Daniëlle Posthuma(Amsterdam Neuroscience), Daniel Schunk(Johannes Gutenberg University Mainz), Murray B. Stein(University of California San Diego), Rauli Svento(University of Oulu), Henning Tiemeier(Erasmus MC), Paul R. H. J. Timmers(Centre for Global Health Research), Patrick Turley(Broad Institute), Robert J. Ursano(Uniformed Services University of the Health Sciences), Gert G. Wagner(German Institute for Economic Research), James F. Wilson(Western General Hospital), Jacob Gratten(Translational Research Institute), James J. Lee(University of Minnesota), David Cesarini(New York University), Daniel J. Benjamin(University of Southern California), Philipp Koellinger(German Institute for Economic Research), Jonathan Beauchamp(University of Toronto)

Nature Genetics

January 9, 2019

10.1038/s41588-018-0309-3

Cited by 838Open Access

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