Late Breaking Abstract - Which treatable traits matter? Prevalence of treatable traits and risk of exacerbation in a random population sample with asthma

Abstract

<b>Introduction:</b> Many candidate treatable traits have been proposed for the management of airways disease. However, trait prevalence in the general asthma population and which traits are associated with future exacerbation risk are unknown. <b>Methods:</b> The prevalence of 17 treatable traits and their association with future exacerbation risk was derived from the previously reported New Zealand Respiratory Health Survey, ACTRN12610000666022. Adults aged 18-75 with symptoms of wheeze and breathlessness, recruited from a random population sample, underwent detailed characterisation with questionnaires, pulmonary function, and biomarkers including blood eosinophils and FeNO. ACQ5 score was a co-variate. <b>Results:</b> 175 participants had both a doctor9s diagnosis of asthma and severe exacerbation data. Traits are shown in figure 1. Six traits were significantly associated with future exacerbation: <b>Conclusions:</b> We have demonstrated that 5 of 17 traits are associated with increased future risk of exacerbation in this population. These traits may be of particular importance for personalised treatment.