A Novel Sensitive Immunoassay Targeting the 5-Methylthio- <scp>d</scp> -Xylofuranose–Lipoarabinomannan Epitope Meets the WHO's Performance Target for Tuberculosis Diagnosis
George B. Sigal(Meso Scale Discovery (United States)), Abraham Pinter(Rutgers, The State University of New Jersey), Todd L. Lowary(University of Alberta), Masanori Kawasaki(Otsuka (Japan)), Andra Li(ImmunoPrecise (Canada)), Anu Mathew(Meso Scale Discovery (United States)), Michael Tsionsky(Meso Scale Discovery (United States)), Ruixiang Blake Zheng(University of Alberta), Tatiana Plisova(Meso Scale Discovery (United States)), Ke Shen(University of Alberta), Kiyonori Katsuragi(Otsuka (Japan)), Alok Choudhary(Rutgers, The State University of New Jersey), William Honnen(Rutgers, The State University of New Jersey), Payam Nahid(University of California, San Francisco), Claudia M. Denkinger(FIND), Tobias Broger(FIND)
Cited by 122Open Access
Abstract
complex and shows no cross-reactivity with fast-growing mycobacteria or other bacteria. The present study provides evidence that improved assay methods and reagents lead to increased diagnostic accuracy. The results of this work have informed the development of a sensitive and specific novel LAM point-of-care assay with the aim to meet the WHO's performance target for TB diagnosis.
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