The long noncoding RNA LINC00312 induces lung adenocarcinoma migration and vasculogenic mimicry through directly binding YBX1

Zhenzi Peng(Central South University), Jun Wang(Central South University), Bin Shan(Washington State University Spokane), Bin Li(Central South University), Wei Peng(Central South University), Yeping Dong(Central South University), Wenwen Shi(Central South University), Wenyuan Zhao(Central South University), Dan He(Central South University), Minghao Duan(Central South University), Yuanda Cheng(Central South University), Chunfang Zhang(Central South University), Chaojun Duan(Central South University)
Molecular Cancer
November 23, 2018
10.1186/s12943-018-0920-z
Cited by 141Open Access
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Abstract

Vasculogenic mimicry (VM) gives rise to tumor neovascularization that is critical for tumor growth and metastasis. Long non-coding RNAs (lncRNAs) have been implicated in diverse and fundamental biological processes. LINC00312 is associated with lung adenocarcinoma. In this study, we found that LINC00312 induced migration, invasion and VM of lung cancer cells by direct binding to the transcription factor Y-Box Binding Protein 1 (YBX1). Moreover, we demonstrated that YBX1 is associated with different fragments within 0-2410 nt 5'region of LINC00312. In addition, LINC00312 is associated with VM in 124 lung adenocarcinoma clinical specimens. The results suggest that LINC00312 is a promising therapeutic and diagnostic target for lung adenocarcinoma.

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